VAMP-2 Antibody

Product Discontinued

VAMP-2 Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 44-93 of VAMP2 according to NP_055047.1.
• Localization: Type IV membrane protein. Neuronal synaptic vesicles
• Marker: Synaptic Vesicles Marker
• Specificity: VAMP2
• Clonality: Polyclonal
• Host: Chicken
• Gene: VAMP2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:10-1:2000
  • Western Blot 1:100-1:2000
• Application Notes: This antibody can be used in Immunocytochemistry and Western Blot. Recommended Starting Dilutions*: ICC: 1/200 Not tested in other applications. *Optimal dilutions should be determined by the end user.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for VAMP-2 Antibody

• FLJ11460
• SYB2
• SYB2vesicle-associated membrane protein 2
• synaptobrevin 2
• synaptobrevin-2
• VAMP2
• VAMP-2
• VAMP-2vesicle associated membrane protein 2
• vesicle-associated membrane protein 2 (synaptobrevin 2)

Background

Synaptobrevins/VAMPs, syntaxins, and the 25 kD synaptosomal associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP2 is a member of the vesicle associated membrane protein (VAMP)/synaptobrevin family. VAMP2 is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. VAMP2 is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: VAMP2
• Entrez:
  • 6844(Human)
  • 22318(Mouse)
  • 24803(Rat)