VAMP-2 Products

Description

Vesicle-associated membrane protein (VAMP), also known as synaptobrevin, is an 18 kDa integral membrane protein localized to the cytoplasmic surface of synaptic vesicle (2). VAMP consists of a proline-rich amino-terminal region, a highly conserved hydrophilic domain, followed by a transmembrane anchor and a carboxylterminal tail (3). Two VAMP homologs, VAMP1 and VAMP2, are differentially expressed in the nervous system (3). VAMP1 expression is localized to neurons involved in modulating overlapping patterns, whereas VAMP2 is found in neurons ssociated with autonomic, sensory and integrative functions. In non-neuronal tissues, VAMP1 is restricted to pancreas and kidney tubular cells, whereas VAMP2 is predominantly expressed in Langerhans islets and glomerular cells (4). Evidences for VAMP

Bioinformatics

Entrez	6844 Human 22318 Mouse 24803 Rat
Uniprot	P63027 Human NP_055047 Human P63045 Rat
Product By Gene ID	6844
Alternate Names	synaptobrevin 2 Synaptobrevin-2 FLJ11460 SYB2vesicle-associated membrane protein 2 VAMP-2vesicle associated membrane protein 2 synaptobrevin-2 vesicle-associated membrane protein 2 (synaptobrevin 2)

Diseases related to VAMP-2

Discover more about diseases related to VAMP-2.

Tetanus
Diabetes Mellitus
Nervousness
Insulin Resistance
Diabetes Mellitus, Non-insulin-dependent
Malignant Neoplasms
Impaired Cognition
Tissue Adhesions
Impairment (finding)
Neurodegenerative Disorders
Paralysis Flaccid
Nerve Degeneration
Alzheimer's Disease
Hyperglycemia
Pituitary Diseases
Pheochromocytoma
Colorectal Cancer
Cognition Disorders
Malignant Tumor Of Colon

Pathways for VAMP-2

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Exocytosis
Transport
Membrane Fusion
Secretion
Localization
Vesicle Fusion
Endocytosis
Glucose Transport
Insulin Secretion
Synaptic Vesicle Exocytosis
Synaptic Transmission
Vesicle Transport
Vesicle Docking
Synaptic Vesicle Fusion
Aging
Proteolysis
Snare Complex Assembly
Rna Interference
Cell Adhesion
Regeneration

Research Areas for VAMP-2

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Membrane Vesicle Markers
Neuronal Cell Markers
Neuroscience
Neurotransmission

PTMs for VAMP-2

Learn more about PTMs related to VAMP-2.

Cleavage
Phosphorylation
Prenylation
Biotinylation
Oxidation
Palmitoylation
Sulphation
Nitrosylation
Hydroxylation
Amidation
Dephosphorylation
Ubiquitination
Glycosylation

Bioinformatics Tool for VAMP-2

Discover related pathways, diseases and genes to VAMP-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.