VAMP-2 Antibody

Product Discontinued

VAMP-2 Antibody Summary

• Immunogen: A synthetic peptide as a part of human Vesicle-associated membrane protein 2 (VAMP-2, Synaptobrevin-2, VAMP2, SYB2) conjugated to an immunogenic carrier protein was used as the immunogen.
• Marker: Synaptic Vesicles Marker
• Specificity: VAMP2.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: VAMP2
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:2000
  • Immunohistochemistry 1:300-1:2000
  • Immunohistochemistry-Paraffin 1:1000
  • Western Blot 1:300-1:2000

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Xenopus.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Whole antisera
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Unpurified
• Reconstitution Instructions: Reconstitute with 0.1 ml sterilized water to desired concentration.

Alternate Names for VAMP-2 Antibody

• FLJ11460
• SYB2
• SYB2vesicle-associated membrane protein 2
• synaptobrevin 2
• synaptobrevin-2
• VAMP2
• VAMP-2
• VAMP-2vesicle associated membrane protein 2
• vesicle-associated membrane protein 2 (synaptobrevin 2)

Background

The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for VAMP-2 Antibody (NB100-91352)(1)

Publication using NB100-91352

• Kong HK, Wong MH, Chan HM, Lo SC. Chronic Exposure of Adult Rats to Low Doses of Methylmercury Induced a State of Metabolic Deficit in the Somatosensory Cortex. J Proteome Res. 2013-08-28 [PMID: 23984759] (WB, Rat)

Bioinformatics

• Gene Symbol: VAMP2
• Entrez:
  • 6844(Human)
  • 22318(Mouse)
  • 24803(Rat)
• Uniprot:
  • P63027()