UVRAG Antibody (953035) [Alexa Fluor™ Plus 555]

• Reactivity: Hu
• Clone: 953035
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 555

UVRAG Antibody (953035) [Alexa Fluor™ Plus 555] Summary

• Specificity: Detects human UVRAG in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for UVRAG Antibody (953035) [Alexa Fluor™ Plus 555]

• beclin 1 binding protein
• DHTX
• disrupted in heterotaxy
• p63
• UV radiation resistance associated gene
• UV radiation resistance-associated gene protein
• UVRAG
• VPS38

Background

UV radiation resistance-associated gene protein, or UVRAG, is a multi-function protein of 699 amino acids involved in the regulation of cellular pathways implicated in membrane trafficking. UVRAG activates the Beclin-1-PI3KC3 complex, a critical element in the autophagy signaling pathway. Binding studies show that UVRAG and Beclin-1 directly interact via their coiled-coil domains and that Beclin-1 functions as a platform for the formation of the Bcl-2-UVRAG-PI3KC3 complex. Chromosomal aberrations involving the UVRAG gene are associated with left-right axis malformation, and mutations in the gene have been associated with colon cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.