USP7 Antibody

Product Discontinued

USP7 Antibody Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residue 1 and 50 of human Ubiquitin Specific Peptidase 7 using the numbering given in entry NP_003461.1 (GeneID 7874).
• Predicted Species: Rat (100%), Porcine (100%), Monkey (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: USP7
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:50 - 1:500
  • Immunofluorescence
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:100-1:500
• Application Notes: For IHC-Paraffin: Epitope exposure with citrate buffer will hinder staining; likely to work with frozen sections.
• Control:

  USP7 Overexpression Lysate

Reactivity Notes

Northern white-cheeked gibbon, Zebra finch (100%).

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: TBS and 0.1% BSA
• Preservative: 0.09% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for USP7 Antibody

• Deubiquitinating enzyme 7
• EC 3.1.2.15
• EC 3.4.19.12
• HAUSP
• HAUSPTEF1
• Herpes virus-associated ubiquitin-specific protease
• Herpesvirus-associated ubiquitin-specific protease
• TEF1
• ubiquitin carboxyl-terminal hydrolase 7
• ubiquitin specific peptidase 7 (herpes virus-associated)
• ubiquitin specific protease 7 (herpes virus-associated)
• Ubiquitin thioesterase 7
• Ubiquitin-specific-processing protease 7
• USP7

Background

Ubiquitin (Ub) is a highly conserved protein found ubiquitously in eukaryotic organisms. The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific processing protease 7 (USP7) is a member of this family that has been shown to interact and stabilize p53. USP7 is also known as ubiquitin carboxyl-terminal hydrolase 7, ubiquitin thioesterase 7, deubiquitinating enzyme 7, Herpes virus-associated ubiquitin-specific protease, HAUSP, TEF1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: USP7
• Entrez:
  • 7874(Human)
  • 252870(Mouse)
• Uniprot:
  • Q93009()