USP7 Products

Antibodies
Lysates
USP7 Knockout 293T Cell Lysat ...
USP7 Knockout 293T Cell Lysate
NBP2-66255
Species: Hu
Applications: WB
USP7 Overexpression Lysate
USP7 Overexpression Lysate
NBL1-17671
Species: Hu
Applications: WB
Proteins
Recombinant Human His6-USP7 P ...
Recombinant Human His6-USP7 Protei...
E-519
Species: Hu
Applications: Enzyme Activity
Formulation Catalog # Availability Price  
Recombinant Human His6-USP7 C ...
Recombinant Human His6-USP7 Cataly...
E-518B
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
USP7 Recombinant Protein Anti ...
USP7 Recombinant Protein Antigen
NBP1-83293PEP
Species: Hu
Applications: AC

Description

HAUSP (also known as deubiquitinating enzyme 7, herpes virus associated ubiquitin specific protease, TEF1, ubiquitin carboxyl terminal hydrolase 7, ubiquitin specific protease 7, ubiquitin thiolesterase 7, and USP7) is a novel p53 interacting protein. HAUSP was identified by mass spectrometry of affinity-purified p53 associated factors by Li et al. HAUSP strongly stabilizes p53 even in the presence of excess MDM2, and also induces p53-dependent cell growth repression and apoptosis. HAUSP has an intrinsic enzymatic activity that specifically de-ubiquitinates p53 both in vivo and in vitro. Expression of a catalytically inactive point mutation of HAUSP in cells increased the levels of p53 ubiquitination and also destabilized p53. Li et al concluded that their findings revealed an important mechanism by which p53 can be stabilized by direct de-ubiquitination and also implied that HAUSP may function as a tumor suppressor in vivo through the stabilization of p53.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Product By Gene ID 7874
Alternate Names
  • EC 3.1.2.15
  • Ubiquitin thioesterase 7
  • EC 3.4.19.12
  • Herpesvirus-associated ubiquitin-specific protease
  • ubiquitin carboxyl-terminal hydrolase 7
  • Deubiquitinating enzyme 7
  • Herpes virus-associated ubiquitin-specific protease
  • ubiquitin specific protease 7 (herpes virus-associated)
  • HAUSPTEF1
  • Ubiquitin-specific-processing protease 7
  • ubiquitin specific peptidase 7 (herpes virus-associated)

Research Areas for USP7

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cell Biology
DNA Repair
Neuroscience
Stem Cell Markers
Ubiquitin Proteasome Pathway

PTMs for USP7

Learn more about PTMs related to USP7.

Ubiquitination
Phosphorylation
Cleavage
Methylation
Acetylation
Dephosphorylation

Bioinformatics Tool for USP7

Discover related pathways, diseases and genes to USP7. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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