Urocortin Antibody (749606)

Images

 
Western blot shows lysates of SH‑SY5Y human neuroblastoma cell line, HepG2 human hepatocellular carcinoma cell line, HeLa human cervical epithelial carcinoma cell line, and HEK293 human embryonic kidney cell line. ...read more
Urocortin was detected in immersion fixed paraffin-embedded sections of human brain using Mouse Anti-Human Urocortin Monoclonal Antibody (Catalog # MAB7447) at 15 µg/mL overnight at 4 °C. Before incubation with the ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clone
749606
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price

Urocortin Antibody (749606) Summary

Immunogen
E. coli-derived recombinant human Urocortin
Arg26-Lys124 (predicted)
Accession # P55089
Specificity
Detects human Urocortin in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
UCN
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.5 ug/mL
  • Immunohistochemistry 8-25 ug/mL
Publications
Read Publication using
MAB7447 in the following applications:

  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Sterile PBS to a final concentration of 0.5 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Urocortin Antibody (749606)

  • MGC129974
  • MGC129975
  • UCN
  • UI
  • UROC
  • Urocortin
  • urocortin, preproprotein
  • UROCUI

Background

Urocortin (UCN, UCN1) is a member of the widely expressed corticotropin releasing factor (CRF) peptide family that includes UCN1-3 and CRF. UCN stimulates cAMP and MAPK pathways via either of two G-protein coupled receptors, CRFR1 and CRFR2, while other family members prefer CRFR1 (CRF) or CRFR2 (UCN2, UCN3). In the brain, UCN has been implicated in counteracting stress-provoked anxiety and suppressing appetite. It also modulates metabolic activity in peripheral tissues and protects the heart from ischemia/reprofusion injury. The UCN cDNA encodes 124 aa, including a 25 aa signal sequence, a 57 aa propeptide, and a 42 aa mature active 5 kDa UCN peptide. The proform of human UCN (aa 26-124, 11 kDa predicted) shares approximately 80% aa sequence identity with mouse and rat UCN.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Urocortin Antibody (MAB7447)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.


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WB
(1)
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(1)
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Bioinformatics

Gene Symbol UCN
Entrez
Uniprot