Western blot shows lysates of SH‑SY5Y human neuroblastoma cell line, HepG2 human hepatocellular carcinoma cell line, HeLa human cervical epithelial carcinoma cell line, and HEK293 human embryonic kidney cell line. ...read more
Urocortin was detected in immersion fixed paraffin-embedded sections of human brain using Mouse Anti-Human Urocortin Monoclonal Antibody (Catalog # MAB7447) at 15 µg/mL overnight at 4 °C. Before incubation with the ...read more
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Protein A or G purified from hybridoma culture supernatant
Sterile PBS to a final concentration of 0.5 mg/mL.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Urocortin Antibody (749606)
UCN1) is a member of the widely expressed corticotropin releasing factor (CRF)
peptide family that includes UCN1-3 and CRF. UCN stimulates cAMP and MAPK
pathways via either of two G-protein coupled receptors, CRFR1 and CRFR2, while
other family members prefer CRFR1 (CRF) or CRFR2 (UCN2, UCN3). In the brain,
UCN has been implicated in counteracting stress-provoked anxiety and
suppressing appetite. It also modulates metabolic activity in peripheral
tissues and protects the heart from ischemia/reprofusion injury. The UCN cDNA
encodes 124 aa, including a 25 aa signal sequence, a 57 aa propeptide, and a 42
aa mature active 5 kDa UCN peptide. The proform of human UCN (aa 26-124, 11 kDa predicted) shares
approximately 80% aa sequence identity with mouse and rat UCN.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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