Urocortin Antibody (749606) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 749606
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

Urocortin Antibody (749606) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human Urocortin
  Arg26-Lys124 (predicted)
  Accession # P55089
• Specificity: Detects human Urocortin in direct ELISAs and Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Urocortin Antibody (749606) [Alexa Fluor® 647]

• MGC129974
• MGC129975
• UCN
• UI
• UROC
• Urocortin
• urocortin, preproprotein
• UROCUI

Background

Urocortin (UCN, UCN1) is a member of the widely expressed corticotropin releasing factor (CRF) peptide family that includes UCN1-3 and CRF. UCN stimulates cAMP and MAPK pathways via either of two G-protein coupled receptors, CRFR1 and CRFR2, while other family members prefer CRFR1 (CRF) or CRFR2 (UCN2, UCN3). In the brain, UCN has been implicated in counteracting stress-provoked anxiety and suppressing appetite. It also modulates metabolic activity in peripheral tissues and protects the heart from ischemia/reprofusion injury. The UCN cDNA encodes 124 aa, including a 25 aa signal sequence, a 57 aa propeptide, and a 42 aa mature active 5 kDa UCN peptide. The proform of human UCN (aa 26-124, 11 kDa predicted) shares approximately 80% aa sequence identity with mouse and rat UCN.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.