UEV2 Antibody

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Western Blot: UEV2 Antibody [NB100-56360] - Detection of UBE2V2 in HL-60 cell lysate with anti-UBE2V2 pcAb this antibody at 2ug/ml.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

UEV2 Antibody Summary

Immunogen
This antibody was generated by immunizing rabbit with a mixture of synthetic peptides containing amino acids 12-28 of human UBE2V2.
Specificity
UBE2V2
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
UBE2V2
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot 2 ug/ml
Control
UEV2 Overexpression Lysate

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.2% gelatin
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for UEV2 Antibody

  • 1 alpha
  • 25-dihydroxyvitamin D3-inducible
  • DDVIT1
  • DDVit-1
  • EDAF-1
  • EDPF1
  • EDPF-1DDVit 1
  • enterocyte differentiation promoting factor
  • Enterocyte differentiation-associated factor 1
  • enterocyte differentiation-associated factor EDAF-1
  • Enterocyte differentiation-promoting factor 1
  • methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of
  • MMS2
  • MMS2MMS2 homolog
  • UBE2V2
  • ubiquitin-conjugating enzyme E2 variant 2
  • Uev2
  • UEV-2
  • Vitamin D3-inducible protein

Background

The differentiation and activation of monocytes (MO) and monocytic cells is modulated by 1alpha,25-dihydroxyvitamin D3 (Vitamin D3). Recently, using mRNA Differential Display technology, Fritsche J, et al have identified a gene which is induced in freshly isolated human blood MO that are cultured for 4 hours with Vitamin D3. This cDNA encodes a putative 16.5 kD protein. The product of this gene has structural homology with yeast MMS2p and human CROC-1), which defines a structurally and functionally conserved Ubc-like protein family. This protein was called Ubiquitin E2 variant (UBE2V2) or MMS2 (methyl methanesulfonate sensitive 2). The yeast UEV protein, Mms2, is required together with Ubc13 for RAD6/RAD18-dependent postreplicative DNA repair in yeast. These proteins also play a central role in the assembly of K63-linked polyubiquitin chains UEV/Ubc complexes have been implicated in the assembly of Lys63-linked polyubiquitin chains that act as a novel signal in postreplicative DNA repair and IkBa kinase activation. Recent crystal structure analysis provides direct evidence that the Mms2/Ubc13 heterodimer is necessary for DNA repair.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

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Bioinformatics

Gene Symbol UBE2V2
Entrez
Uniprot