UEV2 Products

Antibodies
UEV2 Antibody
UEV2 Antibody
NB100-56360
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
UEV2 Antibody - BSA Free
UEV2 Antibody - BSA Free
NBP2-95241
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Rabbit Polyclonal
Formulation Catalog # Availability Price  
Lysates
UEV2 Overexpression Lysate
UEV2 Overexpression Lysate
NBL1-17548
Species: Hu
Applications: WB
Proteins
Recombinant Human UEV2 His Pr ...
Recombinant Human UEV2 His Protein
NBP1-45295
Species: Hu
Applications: PAGE

Description

The differentiation and activation of monocytes (MO) and monocytic cells is modulated by Vitamin D3. Recently, using mRNA Differential Display technology, Fritsche J, et al have identified a gene which is induced in freshly isolated human blood MO that are cultured for 4 hours with Vitamin D3. This cDNA encodes a putative 16.5 kD protein. The product of this gene has structural homology with yeast MMS2P and human CROC-1, which defines a structurally and functionally conserved UBC-like protein family. This protein was called UEV2. The yeast UEV protein is required together with UBC13 for RAD6/RAD18-dependent postreplicative DNA repair in yeast. These proteins also play a central role in the assembly of K63-linked polyubiquitin chains UEV/UBC complexes have been implicated in the assembly of Lys63-linked polyubiquitin chains that act as a novel signal in postreplicative DNA repair and IkBa kinase activation. Recent crystal structure analysis provides direct evidence that the UEV2 heterodimer is necessary for DNA repair.

Bioinformatics

Entrez Mouse
Human
Uniprot Human
Human
Human
Human
Human
Alternate Names
  • 1 alpha
  • 25-dihydroxyvitamin D3-inducible
  • DDVIT1
  • DDVit-1
  • EDAF-1
  • EDPF1
  • EDPF-1DDVit 1
  • enterocyte differentiation promoting factor
  • Enterocyte differentiation-associated factor 1
  • enterocyte differentiation-associated factor EDAF-1
  • Enterocyte differentiation-promoting factor 1
  • methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of
  • MMS2MMS2 homolog
  • ubiquitin-conjugating enzyme E2 variant 2
  • UEV2
  • UEV-2
  • Vitamin D3-inducible protein

Research Areas for UEV2

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Core ESC-Like Genes
Stem Cell Markers