UBQLN4/CIP75 Antibody

Images

 
Western Blot: UBQLN4/CIP75 Antibody [NBP1-77054] - 3T3 cell lysate with UBQLN4/CIP75 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry-Paraffin: UBQLN4/CIP75 Antibody [NBP1-77054] - Mouse kidney tissue with UBQLN/CIP75 antibody at 5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

UBQLN4/CIP75 Antibody Summary

Immunogen
Antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CIP75. The immunogen is located within the first 50 amino acids of CIP75.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
UBQLN4
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1-2 ug/ml
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 5 ug/ml
Control Peptide
UBQLN4/CIP75 Peptide (NBP1-77054PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for UBQLN4/CIP75 Antibody

  • A1Uataxin-1 ubiquitin-like interacting protein
  • Ataxin-1 ubiquitin-like-interacting protein A1U
  • C1orf6ubiquilin-4
  • chromosome 1 open reading frame 6
  • UBINCIP75
  • ubiquilin 4

Background

The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol UBQLN4
Uniprot