UACA Antibody

Images

 
Independent Antibodies: Western Blot: UACA Antibody [NB100-61622] - Detection of Human UACA by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. ...read more
Immunohistochemistry: UACA Antibody [NB100-61622] - Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti- UACA used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
Immunohistochemistry-Paraffin: UACA Antibody [NB100-61622] - FFPE section of human ovarian carcinoma. Affinity purified rabbit anti-UACA used at a dilution of 1:250.
Immunohistochemistry-Paraffin: UACA Antibody [NB100-61622] - FFPE section of human breast carcinoma. Affinity purified rabbit anti-UACA used at a dilution of 1:250.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P, IP, WB (-)
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml
Validated by:
 

Independent Antibodies

       

Order Details

UACA Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 675 and 725 of human uveal autoantigen with coiled-coil domains and ankyrin repeats using the numbering given in entry NP_060473.2 (GeneID 55075).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
UACA
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:100-1:500
  • Immunoprecipitation 2-5 ug/mg lysate
Application Notes
This antibody is not recommended for Western Blot analysis.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for UACA Antibody

  • FLJ10128
  • KIAA1561MGC141969
  • MGC141967
  • nuclear membrane binding protein
  • NUCLING
  • uveal autoantigen with coiled coil domains and ankyrin repeats
  • uveal autoantigen with coiled-coil domains and ankyrin repeats

Background

UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats) was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol UACA
Entrez
Uniprot