Tumstatin/COL4A3 Antibody (762102) [mFluor Violet 500 SE]

• Reactivity: Hu
• Applications: WB
• Clone: 762102
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: mFluor Violet 500 SE

Tumstatin/COL4A3 Antibody (762102) [mFluor Violet 500 SE] Summary

• Immunogen: E. coli-derived recombinant human Tumstatin
• Specificity: Detects human Tumstatin in direct ELISAs. In direct ELISAs, less than 25% cross-reactivity with recombinant human Collagen IV alpha 1 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: COL4A3
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Tumstatin/COL4A3 Antibody (762102) [mFluor Violet 500 SE]

• COL4A3
• collagen alpha-3(IV) chain
• collagen IV, alpha-3 polypeptide
• collagen, type IV, alpha 3 (Goodpasture antigen)
• Goodpasture antigen
• Tumstatin

Background

COL4A3 (Collagen, type IV, alpha 3) belongs to the type IV collagen family. Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Type IV collagen is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: COL4A3