Tumstatin/COL4A3 Antibody (762102) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: WB
• Clone: 762102
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

Tumstatin/COL4A3 Antibody (762102) [Alexa Fluor® 488] Summary

• Immunogen: E. coli-derived recombinant human Tumstatin
• Specificity: Detects human Tumstatin in direct ELISAs. In direct ELISAs, less than 25% cross-reactivity with recombinant human Collagen IV alpha 1 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Tumstatin/COL4A3 Antibody (762102) [Alexa Fluor® 488]

• COL4A3
• collagen alpha-3(IV) chain
• collagen IV, alpha-3 polypeptide
• collagen, type IV, alpha 3 (Goodpasture antigen)
• Goodpasture antigen
• Tumstatin

Background

Tumstatin is a naturally occurring, anti-angiogenic, anti-tumor peptide of 28 kDa that constitutes the NC1 (non-collagenous) domain of the Collagen IV a3 chain [amino acids (aa) 1427-1670 of Coll IV a3;]. It is liberated from basement membranes by MMP-9, and interacts with Integrin aVb3 on endothelial cells, causing cell cycle arrest, or apoptosis of cells that are proliferating. Human Tumstatin is also active on mouse and bovine endothelial cells. Human Tumstatin shares 91% and 89% aa sequence identity with mouse and rat Tumstatin, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.