TSC22/TSC22D1 Antibody [Unconjugated]

• Reactivity: Mu, Rt
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

TSC22/TSC22D1 Antibody [Unconjugated] Summary

• Immunogen: E. coli-derived recombinant mouse TSC22
  Met1-Ala143
  Accession # P62500.2
• Specificity: Detects mouse and rat TSC22 in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: TSC22D1
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TSC22/TSC22D1 Antibody [Unconjugated]

• Cerebral protein 2
• Egr5
• KIAA1994
• MGC17597
• Regulatory protein TSC-22
• RP11-269C23.2
• TGFB1I4
• TGFB-stimulated clone 22 homolog
• transforming growth factor beta 1 induced transcript 4
• Transforming growth factor beta-1-induced transcript 4 protein
• transforming growth factor beta-stimulated protein TSC-22
• TSC22 domain family 1
• TSC22 domain family protein 1
• TSC22 domain family, member 1
• TSC22
• TSC22D1
• TSC22DKFZp686O19206

Background

Mouse TSC22 is an intracellular 18 kDa (143 aa) protein that belongs to the TSC22/Dip/Bun family of leucine zipper transcription regulators. Family members share a highly conserved central TSC box-leucine zipper domain that is important for dimerization and distinct N- and C-termini that participate in transcriptional regulation. TSC22 can homodimerize or heterodimerize with other family members to function as a repressive transcription factor. Mouse TSC22 shares 100% and 98.5% amino acid sequence homology with rat and human TSC22, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TSC22/TSC22D1 Antibody (AF3779)(1)

Publication using AF3779

• Kato M, Wang L, Putta S, Wang M, Yuan H, Sun G, Lanting L, Todorov I, Rossi JJ, Natarajan R Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells. J. Biol. Chem., 2010-08-16;285(44):34004-15. 2010-08-16 [PMID: 20713358] (IHC, Western Blot, Mouse)

Bioinformatics

• Gene Symbol: TSC22D1
• Uniprot:
  • P62500.2()