Tryptophan Hydroxylase 1/TPH-1 Antibody

Western Blot: Tryptophan Hydroxylase 1/TPH-1 Antibody [H00007166-B01P] - Analysis of TPH1 expression in transfected 293T cell line by TPH1 polyclonal antibody. Lane1:TPH1 transfected lysate(48.84 KDa). Lane2:Non-transfected lysate.

Product Discontinued

Tryptophan Hydroxylase 1/TPH-1 Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: TPH1 (NP_004170.1, 1 a.a. - 444 a.a.) full-length human protein. MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: TPH1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: It has been used for WB and Functional.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein G purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Tryptophan Hydroxylase 1/TPH-1 Antibody

• EC 1.14.16
• EC 1.14.16.4
• indoleacetic acid-5-hydroxylase
• L-tryptophan hydroxylase
• MGC119994
• TPH
• TPH-1
• TPRH
• TRPH
• tryptophan 5-hydroxylase 1
• Tryptophan 5-monooxygenase 1
• tryptophan hydroxylase (tryptophan 5-monooxygenase)
• Tryptophan Hydroxylase 1

Background

Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin (5-HT) and might be related to the pathogenesis of major depression (MD). Two isoforms are known, TPH1 and TPH2. (1). TPH1 is phosphorylated by cAMP-dependent protein kinase A (2). Recently, it has been shown that expression of the TPH1 gene is increased in lungs and pulmonary endothelial cells from patients with idiopathic pulmonary arterial hypertension. Results indicate that TPH1 and peripheral serotonin play an essential role in the development of hypoxia-induced elevations in pulmonary pressures and hypoxia-induced pulmonary vascular remodeling. In addition, the results suggest that, in mice, serotonin has differential effects on the pulmonary vasculature and right ventricular hypertrophy (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TPH1
• Uniprot:
  • NP_004170.1(Human)