Tryptophan Hydroxylase 1/TPH-1 Products

Antibodies
Tryptophan Hydroxylase 1/TPH- ...
Tryptophan Hydroxylase 1/TPH-1 Ant...
AF5276
Species: Hu
Applications: WB, IHC
Host: Goat Polyclonal
Tryptophan Hydroxylase 1/TPH- ...
Tryptophan Hydroxylase 1/TPH-1 [p ...
PPS039
Species: Hu, Mu, Rt, Bv, Ca, Ch, Pm, Rb, Xp, Ze
Applications: WB
Host: Rabbit Polyclonal
Tryptophan Hydroxylase 1/TPH- ...
Tryptophan Hydroxylase 1/TPH-1 [p ...
PPS063
Species: Hu, Mu, Rt, Xp
Applications: WB
Host: Rabbit Polyclonal
Lysates
Tryptophan Hydroxylase 1/TPH- ...
Tryptophan Hydroxylase 1/TPH-1 Ove...
H00007166-T01
Species: Hu
Applications: WB
Tryptophan Hydroxylase 1/TPH- ...
Tryptophan Hydroxylase 1/TPH-1 Ove...
NBL1-17216
Applications: WB
Proteins
Tryptophan Hydroxylase 1/TPH- ...
Tryptophan Hydroxylase 1/TPH-1 Rec...
H00007166-P01
Species: Hu
Applications: WB, ELISA, PA
Tryptophan Hydroxylase 1/TPH- ...
Tryptophan Hydroxylase 1/TPH-1 Par...
H00007166-Q01
Species: Hu
Applications: WB, ELISA, PA
Tryptophan Hydroxylase 1/TPH- ...
Tryptophan Hydroxylase 1/TPH-1 Rec...
NBP1-86922PEP
Species: Hu
Applications: AC
RNAi
Tryptophan Hydroxylase 1/TPH- ...
Tryptophan Hydroxylase 1/TPH-1 RNAi
H00007166-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin (5-HT) and might be related to the pathogenesis of major depression (MD). Two isoforms are known, TPH1 and TPH2. (1). TPH1 is phosphorylated by cAMP-dependent protein kinase A (2). Recently, it has been shown that expression of the TPH1 gene is increased in lungs and pulmonary endothelial cells from patients with idiopathic pulmonary arterial hypertension. Results indicate that TPH1 and peripheral serotonin play an essential role in the development of hypoxia-induced elevations in pulmonary pressures and hypoxia-induced pulmonary vascular remodeling. In addition, the results suggest that, in mice, serotonin has differential effects on the pulmonary vasculature and right ventricular hypertrophy (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Rat
Rat
Product By Gene ID 7166
Alternate Names
  • EC 1.14.16
  • EC 1.14.16.4
  • tryptophan 5-hydroxylase 1
  • TRPH
  • L-tryptophan hydroxylase
  • TPRH
  • indoleacetic acid-5-hydroxylase
  • Tryptophan 5-monooxygenase 1
  • MGC119994
  • tryptophan hydroxylase (tryptophan 5-monooxygenase)
  • TPH
  • tryptophan hydroxylase 1

Research Areas for Tryptophan Hydroxylase 1/TPH-1

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism
Neuroscience
Neurotransmission
Phospho-Specific

PTMs for Tryptophan Hydroxylase 1/TPH-1

Learn more about PTMs related to Tryptophan Hydroxylase 1/TPH-1.

Phosphorylation
Hydroxylation
Cleavage
Nitration
Reduction
Methylation
Oxidation

Bioinformatics Tool for Tryptophan Hydroxylase 1/TPH-1

Discover related pathways, diseases and genes to Tryptophan Hydroxylase 1/TPH-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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