TRPV6 Antibody - BSA Free

Western Blot: TRPV6 Antibody - BSA Free [NBP3-45715] - Human placenta tissue were subjected to SDS PAGE followed by western blot with (TRPV6 Antibody) at dilution of 1:1000

Immunoprecipitation: TRPV6 Antibody - BSA Free [NBP3-45715] - IP Result of anti-TRPV6 (IP:, 4ug; Detection: 1:300) with mouse kidney tissue lysate 4000ug.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

TRPV6 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit TRPV6 Antibody - BSA Free (NBP3-45715) is a polyclonal antibody validated for use in WB, ELISA, ICC/IF and IP. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: transient receptor potential cation channel, subfamily V, member 6. (Uniprot# Q9H1D0)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TRPV6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence 1:10-1:100
  • Immunoprecipitation 1:200-1:1000
  • Western Blot 1:500-1:5000
• Application Notes: Theoretical Molecular Weight is 82 kDa, 70 kDa

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS, 50% Glycerol, pH (7.3)
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for TRPV6 Antibody - BSA Free

• ABP/ZF
• calcium channel CaT1
• Calcium transport protein 1
• CaT1
• CATL
• CaT-L
• CaT-like
• ECAC2
• ECAC2caT-L
• epithelial apical membrane calcium transporter/channel CaT1
• Epithelial calcium channel 2Alu-binding protein with zinc finger domain
• HSA277909
• LP6728
• transient receptor potential cation channel subfamily V member 6
• transient receptor potential cation channel, subfamily V, member 6
• TRPV6
• ZFAB

Background

Calcium-permeable channels, such as TRPV6, participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger. Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA); FUNCTION: Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. SUBUNIT: Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with BSPRY. Interacts with calmodulin. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TRPV6