TRPV6 Products

Description

FUNCTION: Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. SUBUNIT: Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5, heterotetramer. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in duodenum, proximal jejunum, cecum, and colon.; SIMILARITY: Belongs to the transient receptor family, TrpV subfamily. SIMILARITY: Contains 5 ANK repeats.

Bioinformatics

Entrez	114246 Rat
Uniprot	Q9R186 Rat
Product By Gene ID	55503
Alternate Names	ABP/ZF calcium channel CaT1 Calcium transport protein 1 CaT1 CATL CaT-L CaT-like ECAC2 ECAC2caT-L epithelial apical membrane calcium transporter/channel CaT1 Epithelial calcium channel 2Alu-binding protein with zinc finger domain HSA277909 LP6728 transient receptor potential cation channel subfamily V member 6 transient receptor potential cation channel, subfamily V, member 6 TRPV6 ZFAB

Research Areas for TRPV6

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Signal Transduction

Related TRPV6 Blog Posts

Check out the latest blog posts on TRPV6.

Winter is coming, and TRPM8 welcomes the cold! TRPM8, or transient receptor potential melastatin 8, is a nonselective cation channel that is activated by cold environments and menthol-like cooling compounds.  While TRPM8 is best known for its location in peripheral nerve endings, it has functio...    Read more.

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