TRPV4 Antibody

Images

 
Western Blot: TRPV4 Antibody [NBP1-20225] - WB on mouse brain lysate (reduced, denatured) using Rabbit antibody to TRPV4 at 1 : 1000 dilution.
Immunohistochemistry-Paraffin: TRPV4 Antibody [NBP1-20225] - IHC on paraffin sections of rat kidney using Rabbit antibody to TRPV4 (300-400): Animal was perfused with Autoperfuser at 100 mmHg with 300 ml PBS and then ...read more
Immunohistochemistry-Paraffin: TRPV4 Antibody [NBP1-20225] - IHC on paraffin sections of rat kidney using Rabbit antibody to TRPV4 (300-400):Animal was perfused with Autoperfuser at 100 mmHg with 300 ml PBS and then ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, IHC, IHC-Fr, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

TRPV4 Antibody Summary

Immunogen
A synthetic peptide from the 1t cytoplasmic loop of mouse TRPV4 (VRL-2) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and human.The location of the epitope is highlighted in green.
Specificity
TRPV4.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TRPV4
Purity
IgG purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 10-50 ug/ml
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin

Reactivity Notes

Mouse, human and rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
No Preservative
Concentration
LYOPH
Purity
IgG purified
Reconstitution Instructions
Reconstitute to desired concentration. Add glycerol (1:1) for additional stability.

Alternate Names for TRPV4 Antibody

  • CMT2Cosmosensitive transient receptor potential channel 4
  • HMSN2C
  • Osm-9-like TRP channel 4
  • OTRPC4SSQTL1
  • transient receptor potential cation channel subfamily V member 4
  • transient receptor potential cation channel, subfamily V, member 4
  • Transient receptor potential protein 12
  • TRP12OSM9-like transient receptor potential channel 4
  • TrpV4
  • Vanilloid receptor-like channel 2
  • Vanilloid receptor-like protein 2
  • vanilloid receptor-related osmotically activated channel
  • Vanilloid receptor-related osmotically-activated channel
  • VRL2
  • VRL-2
  • VR-OAC
  • VROACSPSMA

Background

TRPV4 is a cation-selective channel, activated in response to systemic osmotic pressure.; FUNCTION: Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.; SUBUNIT: Interacts with calmodulin. Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES.; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.; TISSUE SPECIFICITY: Expressed lung, spleen, kidney, testis, fat, and at very low levels in trigeminal ganglia.; SIMILARITY: Belongs to the transient receptor family, TrpV subfamily.; SIMILARITY: Contains 3 ANK repeats.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Discover related pathways, diseases and genes to TRPV4 Antibody (NBP1-20225). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Bioinformatics

Gene Symbol TRPV4
Entrez
Uniprot