Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Hu, Mu, Rt, PmApplications:
WB, ICC/IF, IHC, IHC-PHost:
Species: Hu, Rt, Po, Bv, Rb
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
TRPV4 is a cation-selective channel, activated in response to systemic osmotic pressure. FUNCTION: Non-selective calcium permanent cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. SUBUNIT: Interacts with calmodulin. Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed lung, spleen, kidney, testis, fat, and at very low levels in trigeminal ganglia. SIMILARITY: Belongs to the transient receptor family, TrpV subfamily. SIMILARITY: Contains 3 ANK repeats.
|Product By Gene ID
- Vanilloid receptor-related osmotically-activated channel
- Vanilloid receptor-like channel 2
- Vanilloid receptor-like protein 2
- Transient receptor potential protein 12
- Osm-9-like TRP channel 4
- vanilloid receptor-related osmotically activated channel
- transient receptor potential cation channel subfamily V member 4
- CMT2Cosmosensitive transient receptor potential channel 4
- TRP12OSM9-like transient receptor potential channel 4
- transient receptor potential cation channel, subfamily V, member 4
Bioinformatics Tool for TRPV4
Discover related pathways, diseases and genes to TRPV4. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.
Related TRPV4 Blog Posts
Check out the latest blog posts on TRPV4.
Read more TRPV4 related blogs.
|Winter is coming, and TRPM8 welcomes the cold!
TRPM8, or transient receptor potential melastatin 8, is a nonselective cation channel that is activated by cold environments and menthol-like cooling compounds. While TRPM8 is best known for its location in peripheral nerve endings, it has functio... Read more.
|OS9: Taking proteins to the ER finish line
The OS9 protein is a lectin/glycoprotein that maintains endoplasmic reticulum (ER) quality control and ER-associated degradation (the so-called ERAD pathway) of newly synthesized proteins. It is essential for the recognition of terminally misfolded no... Read more.
|Touch Infographic: From Touch Receptors to the Brain
The body contains thousands of receptors and nerves which allow us to experience the sense of touch, also referred to as tactile perception. The somatosensory system allows organisms to perceive and decode a wide range of tactile stimuli to allow for... Read more.