TRPV4 Products

Description

TRPV4 is a cation-selective channel, activated in response to systemic osmotic pressure. FUNCTION: Non-selective calcium permanent cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. SUBUNIT: Interacts with calmodulin. Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed lung, spleen, kidney, testis, fat, and at very low levels in trigeminal ganglia. SIMILARITY: Belongs to the transient receptor family, TrpV subfamily. SIMILARITY: Contains 3 ANK repeats.

Bioinformatics

Entrez	59341 Human 63873 Mouse 66026 Rat
Uniprot	NM_021625 Human NM_147204 Human Q9EPK8 Mouse Q9HBA0 Human
Product By Gene ID	59341
Alternate Names	CMT2Cosmosensitive transient receptor potential channel 4 HMSN2C Osm-9-like TRP channel 4 OTRPC4SSQTL1 transient receptor potential cation channel subfamily V member 4 transient receptor potential cation channel, subfamily V, member 4 Transient receptor potential protein 12 TRP12OSM9-like transient receptor potential channel 4 TrpV4 Vanilloid receptor-like channel 2 Vanilloid receptor-like protein 2 vanilloid receptor-related osmotically activated channel Vanilloid receptor-related osmotically-activated channel VRL2 VRL-2 VR-OAC VROACSPSMA

Related TRPV4 Blog Posts

Check out the latest blog posts on TRPV4.

Winter is coming, and TRPM8 welcomes the cold! TRPM8, or transient receptor potential melastatin 8, is a nonselective cation channel that is activated by cold environments and menthol-like cooling compounds.  While TRPM8 is best known for its location in peripheral nerve endings, it has functio...    Read more.

Touch Infographic: From Touch Receptors to the Brain The body contains thousands of receptors and nerves which allow us to experience the sense of touch, also referred to as tactile perception. The somatosensory system allows organisms to perceive and decode a wide range of tactile stimuli to allow for ...    Read more.

OS9: Taking proteins to the ER finish line The OS9 protein is a lectin/glycoprotein that maintains endoplasmic reticulum (ER) quality control and ER-associated degradation (the so-called ERAD pathway) of newly synthesized proteins. It is essential for the recognition of terminally misfolded no...    Read more.

Read more TRPV4 related blogs.