TRPM6 Products

RNAi
TRPM6 RNAi
TRPM6 RNAi
H00140803-R03
Species: Hu
Applications: RNAi, RNAi SP

Description

FUNCTION: Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Forms heterodimers with TRPM7. TRPM6 requires the presence of TRPM7 to be targeted to the cell membrane (in HEK 293 cells).; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.; TISSUE SPECIFICITY: Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in H510 small cell lung carcinoma cells.

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 140803
Alternate Names
  • transient receptor potential cation channel subfamily M member 6
  • FLJ22628
  • HSH
  • EC 2.7.11.1
  • HOMG1
  • Melastatin-related TRP cation channel 6
  • HOMG
  • Channel kinase 2
  • CHAK2HMGX
  • hypomagnesemia, secondary hypocalcemia
  • transient receptor potential cation channel, subfamily M, member 6

PTMs for TRPM6

Learn more about PTMs related to TRPM6.

Phosphorylation
Glycosylation
Biotinylation
Reduction
Oxidation
Deglycosylation

Bioinformatics Tool for TRPM6

Discover related pathways, diseases and genes to TRPM6. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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