TRPC4 Antibody


There are currently no images for TRPC4 Antibody (NB200-605).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Reactivity Mu, RtSpecies Glossary
Applications WB, IHC, IHC-Fr, IHC-P
1.0 mg/ml

Order Details

TRPC4 Antibody Summary

Synthetic peptide: CKEKHAHEEDSSIDYDL, corresponding to amino acids 943-958 of Mouse TRPC4.
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
PBS (pH 7.4), 1.0% BSA and 5% Sucrose
0.025% Sodium Azide
1.0 mg/ml
Immunogen affinity purified


  • Western Blot 1:200
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
Predicted molecular weight: 117 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Reactivity Notes

Cross-reacts with Rat and Mouse. Expected to cross-react with Human due to sequence identity. Not yet tested in other species.

Alternate Names for TRPC4 Antibody

  • hTrp4
  • hTrp-4
  • MGC119570
  • MGC119571
  • MGC119572
  • MGC119573
  • short transient receptor potential channel 4
  • transient receptor potential 4
  • transient receptor potential cation channel, subfamily C, member 4
  • TrpC4
  • Trp-related protein 4


Cytosolic Ca2+ serves as an intracellular mediator for many extracellular signals. At rest, cells maintain a low Ca2+ concentration of ~ 10-7 M. Upon activation of the phospholipase C-dependent mechanism, the cytosolic Ca2+ concentration rises. In many vertebrate and invertebrate cells, the influx of Ca2+ is biphasic. Mobilization of Ca2+ from internal stores (sarcoplasmic reticulum in muscle cells and endoplasmic reticulum in other cell types) drives the initial burst. The second phase, referred to as capacitative Ca2+ entry (CCE) or store-operated Ca2+ entry, occurs when the depletion of intracellular Ca2+ stores activates a non-voltagesensitive plasma membrane Ca2+ conductance.1 The channels responsible for this conductance have been referred to as SOCs for store-operated channels. A Drosophila gene, trp (transient receptor potential), encodes the first identified candidate for such a channel. In recent years, seven mammalian TRP channels, named TRPC1-TRPC7, have been cloned. TRP channels (TRPCs) are ubiquitous, yet are most abundant in muscles and nerves. They differ in their method of activation and in their channel conductance.2 All TRPCs have six transmembrane segments with a pore-forming loop between the fifth and sixth segment. This structure is similar to the pore-forming subunits of other channels including voltage-gated Na+, K+ and Ca2+ channels and cyclic nucleotide gated channels. The TRP isoforms can be divided into three subfamilies based on characteristic sequence domains. The long TRP channels (LTRPCs) have four related sequences with open reading frames (ORFs) coding for approximately 1600 amino acids. The other two subfamilies are characterized by shorter ORFs, coding for about 900 amino acids. These are called the short TRP (STRP) and osm-9-like (OTRP) channel families. The OTRPCs are named after the first member of this family to be identified, the C. elegans clone osm-9.2 The sub-families differ in other ways. STRPCs have two to four ankyrin domains in their N-terminal cytosolic tail, where as OTRPCs have three or more and LTRPCs have none. Furthermore, a proline-rich motif in the cytosolic C-terminal region near the sixth transmembrane segment can be found in STRPCs and LTRPCs, but not in OTRPCs.2 The sub-families also differ in their functional properties. The seven mammalian TRPCs (TRPCs 1-7) are all members of the STRPC sub-family. STRPCs are activated in response to phospholipase C activation. OTRPCs appear to be activated by physical or chemical stimuli such as heat, osmotic stress or mechanical stress. The function and activation of LTRPCs is not yet known since their ability to function as channels has not been demonstrated. TRPC4 has been identified in adrenal gland, testis and brain.2 Full-length cDNAs have been cloned from bovine, human, mouse and rat species. TRPC4 is a non-selective cation channel that integrates signaling pathways from G-protein-coupled receptors and receptor tyrosine kinases independently of the depletion of calcium stores.3


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Species: Hu, Mu
Applications: Flow, ICC/IF, IHC-Fr
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Species: Hu, Mu
Applications: WB, DB, IHC, IHC-P
Species: Hu, Mu
Applications: WB, IP, PEP-ELISA
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-Fr, IHC-P, IP
Species: Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-Fr
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P, IP
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, ELISA, ICC/IF, S-ELISA
Species: Hu
Applications: WB, IHC, IHC-Fr, IHC-P
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IP, S-ELISA
Species: Hu
Applications: WB, IP
Species: Hu, Rt, Pm
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Species: Hu, Mu(-)
Applications: WB, IP
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, ELISA, ICC/IF, S-ELISA
Species: Hu, Mu
Applications: WB, ICC/IF, IHC-P, IP
Species: Mu, Rt
Applications: WB, IHC, IHC-Fr, IHC-P

Publications for TRPC4 Antibody (NB200-605) (0)

There are no publications for TRPC4 Antibody (NB200-605).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for TRPC4 Antibody (NB200-605) (0)

There are no reviews for TRPC4 Antibody (NB200-605). By submitting a review earn points towards our Rewards Program.
  • 250 points for product review
  • 500 additional points for an image with your product review
  • Double points (500) if you are the first to review this product
  • Double points (1000) if you are the first to review this product with an image

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for TRPC4 Antibody (NB200-605) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Additional TRPC4 Antibody Products

Related Products by Gene

Bioinformatics Tool for TRPC4 Antibody (NB200-605)

Discover related pathways, diseases and genes to TRPC4 Antibody (NB200-605). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for TRPC4 Antibody (NB200-605)

Discover more about diseases related to TRPC4 Antibody (NB200-605).

Pathways for TRPC4 Antibody (NB200-605)

View related products by pathway.

PTMs for TRPC4 Antibody (NB200-605)

Learn more about PTMs related to TRPC4 Antibody (NB200-605).

Research Areas for TRPC4 Antibody (NB200-605)

Find related products by research area.

Blogs on TRPC4

There are no specific blogs for TRPC4, but you can read our latest blog posts.

Contact Information

Product PDFs


Gene Symbol TRPC4

Customer Resources

Novus Review - Submit your review and earn rewards points which can be used for merchandise & discounts.
Risk Free Testing - Test on a species/application not listed above to receive a full credit towards a future purchase.

Novus' Quality Guarantee - Novus guarantees that every product we sell will work in the application and species listed on our website and datasheets.

Submit your question on NB200-605 below.
During business hours, we will respond to your email within 24 hours. For any questions submitted on the weekend, a response will be received on Monday.
For immediate assistance during business hours M- F (excluding major holidays), please contact us.
Ask a Scientist - We have a lab full of white coats just waiting for your scientific questions and concerns.

Customers Who Bought This Also Bought