TrkC Antibody [Phycoerythrin]

• Applications: Flow
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Phycoerythrin

TrkC Antibody [Phycoerythrin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human TrkC
  Cys32-Asp428
  Accession # Q16288
• Specificity: Detects human TrkC in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human TrkB is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: NTRK3
• Purity Statement: Antigen Affinity-purified

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

The neurotrophins, including NGF, BDNF, NT-3 and NT-4/5, constitute a group of structurally related, secreted proteins that play an important role in the development and function of the nervous system. The biological activities of the neurotrophins are mediated by binding to and activating two unrelated receptor types: the p75 neurotrophin receptor (p75^NTR) and the Trk family of receptor tyrosine kinases. p75^NTR is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF16. Although it binds all neurotrophins with low-affinity, it complexes with the Trks to form high affinity neurotrophin receptors, and with Sortilin to form high affinity receptors for the proneurotrophins. Three Trk family proteins, TrkA, TrkB and TrkC, that exhibit different ligand specificities have been identified. TrkA binds NGF and NT‑3, TrkB binds BDNF, NT-3 and NT-4/5, and TrkC binds NT-3 and BDNF. All Trk family proteins share a conserved, complex subdomain organization consisting of two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in their extracellular region, as well as an intracellular region that contains a tyrosine kinase domain. Natural splice variants of the different Trks, lacking the first cysteine-rich domain, the first and second or all three of the leucine-rich motifs, or the tyrosine kinase domain, have been described. At the protein sequence level, Trks are highly conserved between species with the extracellular domains of human and mouse TrkC showing 94% amino acid sequence identity. The proteins also exhibit cross-species activity. The 135-140 kDa full-length form of TrkC has been found in select embryonic tissues (dorsal root ganglia neurons; renal collecting ducts) and multiple adult cell types, including cortical neurons, astrocytes, endothelial cells, vascular smooth muscle cells, melanocytes, ovarian granulosa cells, and neural stem cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NTRK3