TREK 1 Antibody

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Western Blot: TREK 1 Antibody [NB110-41535] - Detection of TREK 1 in membrane lysate fraction of human brain tissue.

Product Details

Summary
Reactivity Hu, Mu, BvSpecies Glossary
Applications WB, ICC/IF (-), IHC (-)
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

TREK 1 Antibody Summary

Immunogen
A synthetic peptide made to an N-terminal region of human TREK 1 (within residues 1-100). [Swiss-Prot# Q9NRT2]
Localization
Membrane
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KCNK2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
Application Notes
This TREK 1 antibody is useful inThis TREK 1 antibody is useful for Western Blot where a band is seen ~47 kDa. Please note that it is essential to run against membrane preps. This antibody is not recommended for Immunohistochemistry or Immunocytochemisrty.
Positive Control
TREK 1 Lysate (NBL1-12182)
Publications
Read Publication using NB110-41535.

Reactivity Notes

Human, mouse, and cow. 88% sequence identity with rat protein.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
Tris-Glycine and 0.15M NaCl
Preservative
0.05% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for TREK 1 Antibody

  • MGC126742
  • MGC126744
  • potassium channel, subfamily K, member 2
  • subfamily K, member 2
  • tandem-pore-domain potassium channel TREK-1
  • TREK-1 K(+) channel subunit
  • TWIK-related potassium channel 1
  • two-pore potassium channel 1

Background

TREK 1 (KCNK2 or two pore potassium channel TPKC1) belongs to two pore domain potassium channel (TC 1.A.1.8) family and it is a TWIK related K+ channel that acts as a background channel producing time/voltage-independent background current which drives the membrane potential toward the K+ equilibrium potential thereby affecting input resistance. TREK1 is characterized by mechanosensitivity, heat sensitivity, G-protein regulation, and activation by lipids, arachidonic acid, and volatile anesthetics such as chloroform, halothane and isoflurane. TREK1 is widely expressed in brain and genetic ablation has revealed involvement of this channel in depression, neuroprotection, pain perception, and ischemia-precipitated epilepsy. TREK1 gene inactivation produces mice with decreased sensitivity to volatile anesthetics, impaired PUFA-mediated neuroprotection and altered pain perception, depression-resistant phenotype and alteration in the efficacy of GPCR-associated cascade producing NO that leads to major endothelial dysfunction.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TREK 1 Antibody (NB110-41535)(1)

We have publications tested in 1 application: WB.


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Product General Protocols

View specific protocols for TREK 1 Antibody (NB110-41535): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB110-41535AF405
Alexa Fluor 488 Labeled NB110-41535AF488
Alexa Fluor 647 Labeled NB110-41535AF647
Alexa Fluor 700 Labeled NB110-41535AF700
Biotin Labeled NB110-41535B
DyLight 405 Labeled NB110-41535V
DyLight 488 Labeled NB110-41535G
DyLight 550 Labeled NB110-41535R
DyLight 650 Labeled NB110-41535C
FITC Labeled NB110-41535F
HRP Labeled NB110-41535H

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Bioinformatics

Gene Symbol KCNK2