KCNK18 Antibody

Images

 
Western Blot: KCNK18 Antibody [NBP1-77097] - Rat brain tissue lysate with KCNK18 antibody at (A) 1 and (B) 2 ug/mL
Immunocytochemistry/ Immunofluorescence: KCNK18 Antibody [NBP1-77097] - Immunofluorescence of TRESK in Rat Brain cells with TRESK antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: KCNK18 Antibody [NBP1-77097] - Rat brain tissue with KCNK18 antibody at 5 ug/mL.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

KCNK18 Antibody Summary

Immunogen
Antibody was raised against a 17 amino acid synthetic peptide from near the center of human TRESK. The immunogen is located within amino acids 210 - 260 of TRESK.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KCNK18
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-2 ug/ml
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Theoretical MW
43.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control Peptide
KCNK18 Peptide (NBP1-77097PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for KCNK18 Antibody

  • K2p18.1
  • potassium channel subfamily K member 18
  • potassium channel, subfamily K, member 18
  • TRESK2
  • TRESK-2
  • TRESKTWIK-related spinal cord potassium channel
  • TRIKMGR13
  • TWIK-related individual K+ channel
  • TWIK-related individual potassium channel
  • TWIK-related spinal cord K+ channel

Background

TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol KCNK18
Entrez
Uniprot