TREK 1 Antibody [DyLight 488]


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Product Details

Reactivity Hu, Mu, BvSpecies Glossary
Applications WB
DyLight 488

TREK 1 Antibody [DyLight 488] Summary

A synthetic peptide made to an N-terminal region of human TREK 1 (within residues 1-100). [Swiss-Prot# Q9NRT2]
Immunogen affinity purified
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  • Western Blot 2 ug/ml
Application Notes
This TREK 1 antibody is useful inThis TREK 1 antibody is useful for Western Blot where a band is seen ~47 kDa. Please note that it is essential to run against membrane preps. This antibody is not recommended for Immunohistochemistry or Immunocytochemisrty.

Reactivity Notes

Human, mouse, and cow. 88% sequence identity with rat protein.

Packaging, Storage & Formulations

Store at 4C in the dark.
50mM Sodium Borate
0.05% Sodium Azide
Immunogen affinity purified


Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for TREK 1 Antibody [DyLight 488]

  • MGC126742
  • MGC126744
  • potassium channel, subfamily K, member 2
  • subfamily K, member 2
  • tandem-pore-domain potassium channel TREK-1
  • TREK-1 K(+) channel subunit
  • TWIK-related potassium channel 1
  • two-pore potassium channel 1


A potential new target for antidepressants. Nature Neuroscience pp 1134-1141. A potassium channel called TREK1 may represent a new target for antidepressant drugs, according to research published in the September issue of Nature Neuroscience. The channel may exert its effects through a signaling pathway in the brain different to that normally targeted by most conventional antidepressants, which are thought to work by increasing the level of the neurotransmitter serotonin in the brain. Michel Lazdunski and colleagues studied mice lacking the gene for the TREK1 channel, which normally contributes to the background currents that set the resting membrane potential of neurons. In several behavioral tests used to model depression, these mice behaved as if they had been treated with an antidepressant. In addition, they had increased serotonergic activity, and did not release as much of the stress hormone corticosterone as normal mice in response to mild stress. Moreover, the authors report that the TREK1 channel was also directly inhibited by conventional antidepressants. The finding that mice lacking the gene for TREK1 behave as if they have been given an antidepressant suggests that small molecule 'blockers' of the potassium channel might be effective therapeutically. If TREK1 is found to exert its antidepressant effects through a pathway independent of serotonin, it is possible that future therapies targeting TREK1 channels may be faster acting and may have fewer side effects than conventional antidepressants. Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype pp. 1134-1141. Heurteaux C, Lucas G, Guy N, El Yacoubi M, Thummler S, Peng XD, Noble F, Blondeau N, Widmann C, Borsotto M, Gobbi G, Vaugeois JM, Debonnel G, Lazdunski M. Published online: 13 Aug 2006 | doi:10.1038/nn1749 TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. As well, it is regulated by various neurotransmitters. It has been shown that alterations in the functioning, regulation, or both of the TREK-1 channel may alter mood. TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs. Therefore, this particular K+ channel emerges as a potential innovative target for developing new therapeutic agents for anesthesiology and neurology, such as antidepressants.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies


Isotype Controls

Other Available Formats

Biotin Labeled NB110-41535B
DyLight 550 Labeled NB110-41535R
DyLight 650 Labeled NB110-41535C
HRP Labeled NB110-41535H

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Gene Symbol KCNK2