Transglutaminase 2/TGM2 Antibody [Alexa Fluor® 350]

• Applications: WB, IP, KO
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 350

Transglutaminase 2/TGM2 Antibody [Alexa Fluor® 350] Summary

• Immunogen: S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Transglutaminase 2/TGM2
  Ala2-Ala687 (Asn533Thr, Leu655Val)
  Accession # P21980
• Specificity: Detects human Transglutaminase 2/TGM2 in direct ELISAs and human, mouse, and rat Transglutaminase 2/TGM2 in Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) TGM3, rhTGM4, and rhTGM7 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Transglutaminase 2 (TG2), encoded by the TGM2 gene, is also known as tissue transglutaminase (tTG), transgluytaminase C (TGC), and protein-glutamine-gamma -glutamyltransferase. It belongs to the family of transglutaminases that catalyze the posttranslational modification of proteins via calcium dependent cross-linking reactions (1-3). In addition to its function in protein cross-linking, TGM2 is also capable of hydrolyzing both GTP and ATP (4) and has intrinsic kinase activity (5). TGM2 has been implicated in a variety of human diseases including celiac disease, inclusion body myositis, atherosclerosis, and neurodegenerative diseases (6-7).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.