TRAIL/TNFSF10 Antibody (75411) [Unconjugated]

Images

 
In the presence of a cross-linking antibody, Mouse polyHistidine Monoclonal Antibody (Catalog # MAB050) and the metabolic inhibitor actinomycin D (1 µg/mL), Recombinant Human TRAIL/TNFSF10 (Catalog # 375-TL) induces ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, B/N
Clone
75411
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price

TRAIL/TNFSF10 Antibody (75411) [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human TRAIL/TNFSF10
Thr95-Gly281
Accession # P50591
Specificity
Detects human TRAIL/TNFSF10 in direct ELISAs.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TNFSF10
Purity Statement
Protein A or G purified from ascites
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 8-25 ug/mL
  • Neutralization 2-8 ng/mL
Publications
Read Publications using
MAB375 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TRAIL/TNFSF10 Antibody (75411) [Unconjugated]

  • Apo-2 ligand
  • APO2L
  • Apo-2Ltumor necrosis factor (ligand) family, member 10
  • APO2Ltumor necrosis factor apoptosis-inducing ligand splice variant delta
  • CD253 antigen
  • CD253
  • Protein TRAIL
  • TL2
  • TNF-related apoptosis-inducing ligand
  • TNFSF10
  • TRAIL
  • TRAILTNF-related apoptosis inducing ligand TRAIL
  • tumor necrosis factor (ligand) superfamily, member 10
  • tumor necrosis factor ligand superfamily member 10

Background

TRAIL is a type II transmembrane protein belonging to the TNF superfamily and is now designated TNFSF10. TRAIL is active as a homotrimer and is produced by a variety of cell types in both the membrane bound form and also as a soluble molecule. It binds to any of the four TRAIL receptors as well as to Osteoprotegerin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

NB100-56618
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-P, Flow-CS
NB100-56116
Species: Hu, Mu, Rt, Ma
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
NB100-56708
Species: Hu, Mu, Rt, Po, Ch, ChHa, Ma
Applications: WB, Simple Western, EM, Flow, HEStain, IB, ICC/IF, IHC, IHC-Fr, IHC-P, CyTOF-ready, IHC-FrFl, KD, KO
H00008837-M01
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, S-ELISA
NB100-56183
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P, IP
AF860
Species: Hu, Mu
Applications: WB, Simple Western, IP
NB100-56104
Species: Hu, Mu, Rt, Ca
Applications: WB, IHC, IHC-Fr, IHC-P, IP
NB100-56098
Species: Hu, Mu, Rt, Ca
Applications: WB, IHC, IHC-P, IP
NB100-56118
Species: Hu, Mu, Rt, Ca, Ma
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P, IP, Flow-IC
NB100-56583
Species: Hu, Rt, Rb
Applications: WB, Flow, IHC, IHC-P, KO
AF887
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, CyTOF-ready, ICFlow
MAB375
Species: Hu
Applications: IHC, B/N

Publications for TRAIL/TNFSF10 Antibody (MAB375)(15)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: Bioassay, ELISA (Capture), ICC, IHC-P, Neutralization.


Filter By Application
Bioassay
(2)
ELISA (Capture)
(1)
ICC
(1)
IHC-P
(1)
Neutralization
(10)
All Applications
Filter By Species
Human
(14)
Mouse
(1)
All Species
Showing Publications 1 - 10 of 15. Show All 15 Publications.
Publications using MAB375 Applications Species
G Wu, C Cheney, Q Huang, DJ Hazuda, BJ Howell, P Zuck Improved Detection of HIV Gag p24 Protein Using a Combined Immunoprecipitation and Digital ELISA Method Frontiers in Microbiology, 2021;12(0):636703. 2021 [PMID: 33796087] (ELISA (Capture), Human) ELISA (Capture) Human
N Lalaoui, D Merino, G Giner, F Vaillant, D Chau, L Liu, T Kratina, B Pal, JR Whittle, N Etemadi, J Berthelet, J Gräsel, C Hall, ME Ritchie, M Ernst, GK Smyth, DL Vaux, JE Visvader, GJ Lindeman, J Silke Targeting triple-negative breast cancers with the Smac-mimetic birinapant Cell Death Differ., 2020;0(0):. 2020 [PMID: 32341449] (Neutralization, Human) Neutralization Human
MM Jørgensen, R Bæk, J Sloth, K Varming, OB Christians, NE Ditlevsen, N Rajaratnam Treatment with intravenous immunoglobulin increases the level of small EVs in plasma of pregnant women with recurrent pregnancy loss J. Reprod. Immunol., 2020;140(0):103128. 2020 [PMID: 32330775] (Bioassay, Human) Bioassay Human
ND Arnold, JA Pickworth, LE West, S Dawson, JA Carvalho, H Casbolt, AT Braithwait, J Iremonger, L Renshall, V Germaschew, M McCourt, P Bland-Ward, H Kowash, AG Hameed, AMK Rothman, MG Frid, AA Roger Thom, HR Evans, M Southwood, NW Morrell, DC Crossman, MKB Whyte, KR Stenmark, CM Newman, DG Kiely, SE Francis, A Lawrie A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension Nat Commun, 2019;10(1):5183. 2019 [PMID: 31729368] (Neutralization, Mouse) Neutralization Mouse
RE Vickman, J Yang, NA Lanman, GM Cresswell, F Zheng, C Zhang, RW Doerge, SA Crist, AD Mesecar, CD Hu, TL Ratliff Cholesterol Sulfotransferase SULT2B1b Modulates Sensitivity to Death Receptor Ligand TNF alpha in Castration Resistant Prostate Cancer Mol. Cancer Res., 2019;0(0):. 2019 [PMID: 30824526] (Neutralization, Human) Neutralization Human
MC Tanzer, N Khan, JA Rickard, N Etemadi, N Lalaoui, SK Spall, JM Hildebrand, D Segal, M Miasari, D Chau, WL Wong, M McKinlay, SK Chunduru, CA Benetatos, SM Condon, JE Vince, MJ Herold, J Silke Combination of IAP antagonist and IFN? activates novel caspase-10- and RIPK1-dependent cell death pathways Cell Death Differ, 2017;0(0):. 2017 [PMID: 28106882] (Neutralization, Human) Neutralization Human
Negative control of TRAIL-R1 signaling by transforming growth factor ?1 in pancreatic tumor cells involves Smad-dependent down regulation of TRAIL-R1 Cell Signal, 2016;28(11):1652-1662. 2016 [PMID: 27492861] (Neutralization, Human) Neutralization Human
Tel J, Smits E, Anguille S, Joshi R, Figdor C, de Vries I Human plasmacytoid dendritic cells are equipped with antigen-presenting and tumoricidal capacities. Blood, 2012;120(19):3936-44. 2012 [PMID: 22966165] (Bioassay, Human) Bioassay Human
Kalb ML, Glaser A, Stary G, Koszik F, Stingl G TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-alpha-mediated antitumor reactivity. J. Immunol., 2012;188(4):1583-91. 2012 [PMID: 22231699] (Neutralization, Human) Neutralization Human
Inglefield JR, Dumitru CD, Alkan SS, Gibson SJ, Lipson KE, Tomai MA, Larson CJ, Vasilakos JP TLR7 Agonist 852A Inhibition of Tumor Cell Proliferation Is Dependent on Plasmacytoid Dendritic Cells and Type I IFN. J. Interferon Cytokine Res., 2008;28(4):253-63. 2008 [PMID: 18439103] (Neutralization, Human) Neutralization Human
Show All 15 Publications.

Reviews for TRAIL/TNFSF10 Antibody (MAB375) (0)

There are no reviews for TRAIL/TNFSF10 Antibody (MAB375). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

FAQs for TRAIL/TNFSF10 Antibody (MAB375) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Additional TRAIL/TNFSF10 Products

Bioinformatics Tool for TRAIL/TNFSF10 Antibody (MAB375)

Discover related pathways, diseases and genes to TRAIL/TNFSF10 Antibody (MAB375). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for TRAIL/TNFSF10 Antibody (MAB375)

Discover more about diseases related to TRAIL/TNFSF10 Antibody (MAB375).
 

Pathways for TRAIL/TNFSF10 Antibody (MAB375)

View related products by pathway.

PTMs for TRAIL/TNFSF10 Antibody (MAB375)

Learn more about PTMs related to TRAIL/TNFSF10 Antibody (MAB375).

Blogs on TRAIL/TNFSF10

There are no specific blogs for TRAIL/TNFSF10, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our TRAIL/TNFSF10 Antibody (75411) [Unconjugated] and receive a gift card or discount.

Bioinformatics

Gene Symbol TNFSF10
Uniprot