TRAIL/TNFSF10 Antibody (75411) [Unconjugated]


In the presence of a cross-linking antibody, Mouse polyHistidine Monoclonal Antibody (Catalog # MAB050) and the metabolic inhibitor actinomycin D (1 µg/mL), Recombinant Human TRAIL/TNFSF10 (Catalog # 375-TL) induces more

Product Details

Reactivity HuSpecies Glossary
Applications IHC, B/N

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TRAIL/TNFSF10 Antibody (75411) [Unconjugated] Summary

Mouse myeloma cell line NS0-derived recombinant human TRAIL/TNFSF10
Accession # P50591
Detects human TRAIL/TNFSF10 in direct ELISAs.
Purity Statement
Protein A or G purified from ascites
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Immunohistochemistry 8-25 ug/mL
  • Neutralization 2-8 ng/mL
Read Publications using
MAB375 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TRAIL/TNFSF10 Antibody (75411) [Unconjugated]

  • Apo-2 ligand
  • APO2L
  • Apo-2Ltumor necrosis factor (ligand) family, member 10
  • APO2Ltumor necrosis factor apoptosis-inducing ligand splice variant delta
  • CD253 antigen
  • CD253
  • Protein TRAIL
  • TL2
  • TNF-related apoptosis-inducing ligand
  • TNFSF10
  • TRAILTNF-related apoptosis inducing ligand TRAIL
  • tumor necrosis factor (ligand) superfamily, member 10
  • tumor necrosis factor ligand superfamily member 10


TRAIL is a type II transmembrane protein belonging to the TNF superfamily and is now designated TNFSF10. TRAIL is active as a homotrimer and is produced by a variety of cell types in both the membrane bound form and also as a soluble molecule. It binds to any of the four TRAIL receptors as well as to Osteoprotegerin.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-P, Flow-CS
Species: Hu, Mu, Rt, Ma
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Species: Hu, Mu, Rt, Po, Ch, ChHa, Ma
Applications: WB, Simple Western, EM, Flow, HEStain, IB, ICC/IF, IHC, IHC-Fr, IHC-P, CyTOF-ready, IHC-FrFl, KD, KO
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, S-ELISA
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P, IP
Species: Hu, Mu
Applications: WB, Simple Western, IP
Species: Hu, Mu, Rt, Ca
Applications: WB, IHC, IHC-Fr, IHC-P, IP
Species: Hu, Mu, Rt, Ca
Applications: WB, IHC, IHC-P, IP
Species: Hu, Mu, Rt, Ca, Ma
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P, IP, Flow-IC
Species: Hu, Rt, Rb
Applications: WB, Flow, IHC, IHC-P, KO
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, CyTOF-ready, ICFlow
Species: Hu
Applications: IHC, B/N

Publications for TRAIL/TNFSF10 Antibody (MAB375)(15)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: Bioassay, ELISA (Capture), ICC, IHC-P, Neutralization.

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Showing Publications 1 - 10 of 15. Show All 15 Publications.
Publications using MAB375 Applications Species
G Wu, C Cheney, Q Huang, DJ Hazuda, BJ Howell, P Zuck Improved Detection of HIV Gag p24 Protein Using a Combined Immunoprecipitation and Digital ELISA Method Frontiers in Microbiology, 2021;12(0):636703. 2021 [PMID: 33796087] (ELISA (Capture), Human) ELISA (Capture) Human
N Lalaoui, D Merino, G Giner, F Vaillant, D Chau, L Liu, T Kratina, B Pal, JR Whittle, N Etemadi, J Berthelet, J Gräsel, C Hall, ME Ritchie, M Ernst, GK Smyth, DL Vaux, JE Visvader, GJ Lindeman, J Silke Targeting triple-negative breast cancers with the Smac-mimetic birinapant Cell Death Differ., 2020;0(0):. 2020 [PMID: 32341449] (Neutralization, Human) Neutralization Human
MM Jørgensen, R Bæk, J Sloth, K Varming, OB Christians, NE Ditlevsen, N Rajaratnam Treatment with intravenous immunoglobulin increases the level of small EVs in plasma of pregnant women with recurrent pregnancy loss J. Reprod. Immunol., 2020;140(0):103128. 2020 [PMID: 32330775] (Bioassay, Human) Bioassay Human
ND Arnold, JA Pickworth, LE West, S Dawson, JA Carvalho, H Casbolt, AT Braithwait, J Iremonger, L Renshall, V Germaschew, M McCourt, P Bland-Ward, H Kowash, AG Hameed, AMK Rothman, MG Frid, AA Roger Thom, HR Evans, M Southwood, NW Morrell, DC Crossman, MKB Whyte, KR Stenmark, CM Newman, DG Kiely, SE Francis, A Lawrie A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension Nat Commun, 2019;10(1):5183. 2019 [PMID: 31729368] (Neutralization, Mouse) Neutralization Mouse
RE Vickman, J Yang, NA Lanman, GM Cresswell, F Zheng, C Zhang, RW Doerge, SA Crist, AD Mesecar, CD Hu, TL Ratliff Cholesterol Sulfotransferase SULT2B1b Modulates Sensitivity to Death Receptor Ligand TNF alpha in Castration Resistant Prostate Cancer Mol. Cancer Res., 2019;0(0):. 2019 [PMID: 30824526] (Neutralization, Human) Neutralization Human
MC Tanzer, N Khan, JA Rickard, N Etemadi, N Lalaoui, SK Spall, JM Hildebrand, D Segal, M Miasari, D Chau, WL Wong, M McKinlay, SK Chunduru, CA Benetatos, SM Condon, JE Vince, MJ Herold, J Silke Combination of IAP antagonist and IFN? activates novel caspase-10- and RIPK1-dependent cell death pathways Cell Death Differ, 2017;0(0):. 2017 [PMID: 28106882] (Neutralization, Human) Neutralization Human
Negative control of TRAIL-R1 signaling by transforming growth factor ?1 in pancreatic tumor cells involves Smad-dependent down regulation of TRAIL-R1 Cell Signal, 2016;28(11):1652-1662. 2016 [PMID: 27492861] (Neutralization, Human) Neutralization Human
Tel J, Smits E, Anguille S, Joshi R, Figdor C, de Vries I Human plasmacytoid dendritic cells are equipped with antigen-presenting and tumoricidal capacities. Blood, 2012;120(19):3936-44. 2012 [PMID: 22966165] (Bioassay, Human) Bioassay Human
Kalb ML, Glaser A, Stary G, Koszik F, Stingl G TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-alpha-mediated antitumor reactivity. J. Immunol., 2012;188(4):1583-91. 2012 [PMID: 22231699] (Neutralization, Human) Neutralization Human
Inglefield JR, Dumitru CD, Alkan SS, Gibson SJ, Lipson KE, Tomai MA, Larson CJ, Vasilakos JP TLR7 Agonist 852A Inhibition of Tumor Cell Proliferation Is Dependent on Plasmacytoid Dendritic Cells and Type I IFN. J. Interferon Cytokine Res., 2008;28(4):253-63. 2008 [PMID: 18439103] (Neutralization, Human) Neutralization Human
Show All 15 Publications.

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Gene Symbol TNFSF10