TRAF3IP1 Antibody

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Immunohistochemistry-Paraffin: TRAF3IP1 Antibody [NBP2-14847] - analysis of TRAF3IP1. Human testis probed with TRAF3IP1 antibody at 5 ug/ml.

Product Details

Summary
Reactivity Hu, PmSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

TRAF3IP1 Antibody Summary

Immunogen
A portion of amino acids 390-440 from human TRAF3IP1 was used as the immunogen for this antibody.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TRAF3IP1
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 5 ug/ml

Reactivity Notes

The TRAF3IP1 amino acid sequence used as immunogen for this antibody is 100% homologous in human, and chimpanzee, 89% in orangutan, and white-cheeked gibbon, 74% in rhesus monkey, 68% in new world monkey, and 63% in panda, opossum, and rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A purified

Alternate Names for TRAF3IP1 Antibody

  • DKFZp434F124
  • Interleukin-13 receptor alpha 1-binding protein 1
  • Microtubule-interacting protein associated with TRAF3
  • microtubule-interacting protein that associates with TRAF3
  • MIPT3interleukin 13 receptor alpha 1-binding protein-1
  • MIP-T3microtubule interacting protein that associates with TRAF3
  • TNF receptor-associated factor 3 interacting protein 1
  • TRAF3-interacting protein 1

Background

TRAF3IP1, or MIP-T3 functions as a down regulator of type I IFN responses, a critical component of the innate immune defense in viral infection (1, 2). TRAF3IP1 is involved in the suppression of IL-13 and is effected through IL-13 induction of STAT6 phosphorylation (1). TRAF3IP1 interacts and inhibits TRAF3 complex formation and subsequent downstream signaling molecules RIG-I, MDA5 RIG-I like innate immune receptor molecules, VISA and MAVS, a pathway which leads to IRF mediated IFN-g responses. Additionally TRAF3IP1 also interferes with the signaling through TBK1 and IKKe a common juncture between RLR and TLR signaling (3, 4). It is TRAF3 interaction and binding with MAVS and inhibition of this complex in RLR signaling pathways as well as TRAF3IP1 regulation of TLR signaling that highlight a potential new target for studying IFN responses and regulating them. Antibody to TRAF3IP1 provides a unique tool to further development of regulators of IFN production.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol TRAF3IP1
Uniprot