TRAF-4 Antibody (SR1969) - BSA Free

Western Blot: TRAF-4 Antibody (SR1969) [NBP3-21648] - Western blot analysis using NBP3-21648 in HeLa cell lysate.

• Reactivity: Hu, Mu
• Applications: WB, Flow, ICC/IF
• Clone: SR1969
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

TRAF-4 Antibody (SR1969) - BSA Free Summary

• Description: Novus Biologicals Rabbit TRAF-4 Antibody (SR1969) - BSA Free (NBP3-21648) is a recombinant monoclonal antibody validated for use in WB, Flow and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: A synthesized peptide derived from human TRAF-4 (Uniprot #: Q9BUZ4)
• Specificity: Detects endogenous levels of total TRAF-4
• Source: HEK293
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: TRAF4
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:50
  • Immunocytochemistry/ Immunofluorescence 1:50-1:200
  • Western Blot 1:1000-1:2000
• Theoretical MW: 54 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS, pH 7.4, 150mM NaCl, 50% glycerol.
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for TRAF-4 Antibody (SR1969) - BSA Free

• CART1
• CART1RING finger protein 83
• Cysteine-rich domain associated with RING and Traf domains protein 1
• Metastatic lymph node gene 62 protein
• MLN 62
• MLN62
• MLN62cysteine-rich domain associated with ring and TRAF domain
• RNF83malignant 62
• TNF receptor-associated factor 4
• TRAF4
• TRAF-4
• tumor necrosis receptor-associated factor 4A

Background

The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TRAF4