TRACP/PAP/ACP5 Antibody (ACP5/1070)

Images

 
Immunohistochemistry-Paraffin: TRACP/PAP/ACP5 Antibody (ACP5/1070) [NBP2-45293] - Formalin-fixed, paraffin-embedded human Spleen stained with TRACP/PAP/ACP5 Antibody (ACP5/1070).
Immunohistochemistry-Paraffin: TRACP/PAP/ACP5 Antibody (ACP5/1070) [NBP2-45293] - Formalin-fixed, paraffin-embedded human Spleen stained with TRAcP Monoclonal Antibody (ACP5/1070)
SDS-Page: TRACP/PAP/ACP5 Antibody (ACP5/1070) [NBP2-45293]

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications Flow, IHC, IHC-P, PAGE, ICC/IF
Clone
ACP5/1070
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.2 mg/ml

Order Details

TRACP/PAP/ACP5 Antibody (ACP5/1070) Summary

Immunogen
Recombinant full-length human ACP5 protein
Localization
Cytoplasmic (Lysosomes)
Marker
Hairy Cell Leukemia Marker
Specificity
It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis.Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher's Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
ACP5
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml
  • SDS-Page
  • Immunofluorescence 0.5 - 1.0 ug/ml
Application Notes
Hu-chromosome location: 19p13.2
Immunohistochemistry-Paraffin 0.5 - 1 ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10 - 20 min followed by cooling at RT for 20 minutes.
Use in Immunohistochemistry reported in scientific literature (PMID 28115279).
Theoretical MW
35 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using
NBP2-45293 in the following applications:

  • IHC
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
10 mM PBS with 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.2 mg/ml
Purity
Protein A or G purified

Alternate Names for TRACP/PAP/ACP5 Antibody (ACP5/1070)

  • ACP5
  • TRACP
  • TRACP-5b
  • TTRRAP

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TRACP/PAP/ACP5 Antibody (NBP2-45293)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC.


Filter By Application
IHC
(1)
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Filter By Species
Mouse
(1)
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FAQs for TRACP/PAP/ACP5 Antibody (NBP2-45293) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-47666AF350
Alexa Fluor 405 NBP2-47666AF405
Alexa Fluor 488 NBP2-47666AF488
Alexa Fluor 532 NBP2-47666AF532
Alexa Fluor 594 NBP2-47666AF594
Alexa Fluor 647 NBP2-47666AF647
Alexa Fluor 700 NBP2-47666AF700
Alexa Fluor 750 NBP2-47666AF750
Allophycocyanin NBP2-47666APC
Allophycocyanin/Cy7 NBP2-47666APCCY7
Biotin NBP2-47666B
DyLight 350 NBP2-47666UV
DyLight 405 NBP2-47666V
DyLight 488 NBP2-47666G
DyLight 550 NBP2-47666R
DyLight 594 NBP2-47666DL594
DyLight 650 NBP2-47666C
DyLight 680 NBP2-47666FR
DyLight 755 NBP2-47666IR
FITC NBP2-47666F
HRP NBP2-47666H
Janelia Fluor 549 NBP2-47666JF549
Janelia Fluor 646 NBP2-47666JF646
PE NBP2-47666PE
PE/Atto594 NBP2-47666PEATT594
PE/Cy5.5 NBP2-47666PECY55
PE/Cy7 NBP2-47666PECY7
PerCP NBP2-47666PCP

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Bioinformatics

Gene Symbol ACP5
Uniprot