TRACP/PAP/ACP5 Antibody (ACP5/1070) [Janelia Fluor® 549]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications Flow, IHC, IHC-P, ICC/IF
Clone
ACP5/1070
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 549

Order Details

TRACP/PAP/ACP5 Antibody (ACP5/1070) [Janelia Fluor® 549] Summary

Immunogen
Recombinant full-length human ACP5 protein
Localization
Cytoplasmic (Lysosomes)
Marker
Hairy Cell Leukemia Marker
Specificity
It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This MAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis.Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher's Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
ACP5
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunofluorescence
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for TRACP/PAP/ACP5 Antibody (ACP5/1070) [Janelia Fluor® 549]

  • ACP5
  • TRACP
  • TRACP-5b
  • TTRRAP

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-47666AF350
Alexa Fluor 405 NBP2-47666AF405
Alexa Fluor 488 NBP2-47666AF488
Alexa Fluor 532 NBP2-47666AF532
Alexa Fluor 594 NBP2-47666AF594
Alexa Fluor 647 NBP2-47666AF647
Alexa Fluor 700 NBP2-47666AF700
Alexa Fluor 750 NBP2-47666AF750
Allophycocyanin NBP2-47666APC
Biotin NBP2-47666B
DyLight 350 NBP2-47666UV
DyLight 405 NBP2-47666V
DyLight 488 NBP2-47666G
DyLight 550 NBP2-47666R
DyLight 594 NBP2-47666DL594
DyLight 650 NBP2-47666C
DyLight 680 NBP2-47666FR
DyLight 755 NBP2-47666IR
FITC NBP2-47666F
HRP NBP2-47666H
Janelia Fluor 549 NBP2-47666JF549
Janelia Fluor 646 NBP2-47666JF646
PE NBP2-47666PE
PerCP NBP2-47666PCP

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Bioinformatics Tool for TRACP/PAP/ACP5 Antibody (NBP2-47666JF549)

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Diseases for TRACP/PAP/ACP5 Antibody (NBP2-47666JF549)

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Contact Information

Learn the difference between western blot and simple western

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Calculators

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Bioinformatics

Gene Symbol ACP5