TNF RII/TNFRSF1B Antibody (EPR1653)

Product Discontinued

TNF RII/TNFRSF1B Antibody (EPR1653) Summary

• Immunogen: A synthetic peptide corresponding to residues on the C-terminus in human TNFR2 was used as an immunogen.
• Clonality: Monoclonal
• Host: Rabbit
• Gene: TNFRSF1B
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:10-100
  • Immunocytochemistry/ Immunofluorescence 1:250-500
  • Immunohistochemistry 1:100-250
  • Immunohistochemistry-Paraffin 1:100-250
  • Immunoprecipitation 1:10-100
  • Western Blot 1:10000-50000

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 0.05% BSA and 50% Glycerol, pH 7.4
• Preservative: 0.01% Sodium Azide
• Purity: Tissue culture supernatant

Notes

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Alternate Names for TNF RII/TNFRSF1B Antibody (EPR1653)

• CD120b antigen
• CD120b
• Etanercept
• p75 TNF receptor
• p75TBPII
• p75TNFR
• soluble TNFR1B variant 1
• TNF RII
• TNFBRp80 TNF-alpha receptor
• TNF-R2
• TNFR2TNFR1B
• TNF-R75
• TNFR80
• TNFRII
• TNF-RII
• TNF-R-II
• TNFR-II
• TNFRSF1B
• tumor necrosis factor beta receptor
• tumor necrosis factor binding protein 2
• Tumor necrosis factor receptor 2
• tumor necrosis factor receptor superfamily member 1B
• tumor necrosis factor receptor superfamily, member 1B
• Tumor necrosis factor receptor type II

Background

TNFR2 is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of TNFR2 in protecting neurons from apoptosis by stimulating antioxidative pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TNF RII/TNFRSF1B Antibody (NBP1-95663)(1)

Publication using NBP1-95663

• Lee Su Mi, Yang SeungHee, Cha Ran-Hui et al. Circulating TNF receptors are significant prognostic biomarkers for idiopathic membranous nephropathy. PLoS One 2014-01-01 [PMID: 25098821]

Bioinformatics

• Gene Symbol: TNFRSF1B
• Entrez:
  • 7133(Human)
• Uniprot:
  • P20333()