TMPRSS2 Antibody (1038127) [Alexa Fluor™ Plus 488]

• Reactivity: Hu
• Clone: 1038127
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 488

TMPRSS2 Antibody (1038127) [Alexa Fluor™ Plus 488] Summary

• Specificity: Detects human TMPRSS2 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TMPRSS2 Antibody (1038127) [Alexa Fluor™ Plus 488]

• EC 3.4.21
• Epitheliasin
• FLJ41954
• NP_001128571.1
• NP_001369649.1
• NP_005647.3
• PP9284
• PRSS10
• Serine protease 10
• TMPRSS2
• transmembrane protease serine 2
• transmembrane protease, serine 2

Background

TMPRSS2 is a transmembrane serine protease.  The TMPRSS2 gene is upregulated by androgenic hormones in prostate cells and downregulated in androgen-independent prostate cancer. The fusion between TMPRSS2 gene and ERG is the most common chromosomal aberration detected in prostate cancer.  In relation to COVID-19, TMPRSS2 is involved in priming the viral spike protein which facilitates viral entry.  TMPRSS2 inhibitors are candidates for treatment options of SARS-CoV-2 and other coronaviruses.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.