TMPRSS2 Products

Antibodies
TMPRSS2 Antibody
TMPRSS2 Antibody
NBP2-38263
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
TMPRSS2 Antibody
TMPRSS2 Antibody
NBP1-20984
Species: Hu
Applications: WB, Simple Western, PEP-ELISA
Host: Goat Polyclonal
TMPRSS2 Antibody (2F4)
TMPRSS2 Antibody (2F4)
H00007113-M05
Species: Hu
Applications: WB, ELISA, S-ELISA
Host: Mouse Monoclonal
ELISA Kits
Human TMPRSS2 ELISA Kit (Colo ...
Human TMPRSS2 ELISA Kit (Colorimet...
NBP2-89170
Species: Hu
Applications: ELISA
Human TMPRSS2 ELISA Kit (Chem ...
Human TMPRSS2 ELISA Kit (Chemilumi...
NBP2-89171
Species: Hu
Applications: ELISA
Lysates
TMPRSS2 Overexpression Lysate ...
TMPRSS2 Overexpression Lysate
NBL1-17121
Species: Hu
Applications: WB
Proteins
Recombinant Human TMPRSS2 GST ...
Recombinant Human TMPRSS2 GST (N-T...
H00007113-Q01
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP
TMPRSS2 Recombinant Protein A ...
TMPRSS2 Recombinant Protein Antigen
NBP2-38263PEP
Species: Hu
Applications: AC

Description

TMPRSS2, also called Epitheliasin in mice, is a 492 amino acid type II transmembrane serine protease located on human chromosome 21q22.3 that encodes at least 2 isoforms. This glycosylated serine protease (theoretical molecular weight 70kDa) is regulated by androgens and expressed on the plasma membrane of human bronchial epithelial cells, nasal goblet cells, small intestine epithelia, gastrointestinal tract, the stomach, kidneys and pancreas, with the greatest abundance found in the prostate gland. While the physiological function of TMPRSS2 remains unknown, the serine protease domain undergoes autocleavage and the 32 kDa domain is secreted enabling its interaction with the extracellular matrix. Fusions between TMPRSS2 and the ETS transcription factor genes ERG, ETV1, and ETV4 have been reported in prostate cancer with the TMPRSS2 ERG gene fusion resulting in ERG overexpression in 40-80% of these cases and often producing a more aggressive phenotype. Androgen signaling is disrupted in prostate cancers with the TMPRSS2 ERG fusion which contributes to the switch from androgen dependent to androgen independent prostate cancer (1,2).

TMPRSS2 has also been shown to play a critical role in the process of viral entry for coronaviruses and influenza viruses thru proteolytic activation of key viral glycoproteins. One pathway for SARS-CoV-2 infection, which causes the COVID-19 disease, involves binding of the SARS-CoV-2 Spike 'S' glycoprotein to the human ACE2 receptor and cleavage of S by TMPRSS2 at the cell surface to facilitate viral entry. TMPRSS2 mediates viral entry in a similar mechanism for other coronaviruses such as SARS-CoV and MERS. The broad-spectrum serine protease inhibitor, Camostat, is a TMPRSS2 inhibitor demonstrated to protect mice with lethal SARS-CoV infections (3).

References

1. Clark, J., Cooper, C. (2009) ETS gene fusions in prostate cancer. Nat Rev Urol 6, 429-439. PMID: 19657377

2. Duffy, MJ. (2014) Chapter One - PSA in Screening for Prostate Cancer: More Good than Harm or More Harm than Good? Adv Clin Chem. 66:1-23. PMID: 25344984

3. Shen LW, Mao HJ, Wu YL, Tanaka Y, Zhang W. (2017) TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections. Biochimie. 142:1-10

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 7113
Alternate Names
  • TMPRSS2
  • NP_001128571.1
  • EC 3.4.21
  • NP_001369649.1
  • NP_005647.3
  • PRSS10
  • EC 3.4.21
  • FLJ41954
  • transmembrane protease serine 2
  • Serine protease 10
  • PP9284
  • transmembrane protease, serine 2

Research Areas for TMPRSS2

Find related products by research area and learn more about each of the different research areas below.

Prostate Cancer

PTMs for TMPRSS2

Learn more about PTMs related to TMPRSS2.

Cleavage
Methylation
Phosphorylation
Acetylation
Ubiquitination
Demethylation
Carboxylation

Bioinformatics Tool for TMPRSS2

Discover related pathways, diseases and genes to TMPRSS2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related TMPRSS2 Blog Posts

Check out the latest blog posts on TMPRSS2.
Blocking SARS-CoV-2 Cell Entry: A potential Strategy Against COVID-19 Pandemic
By Jamshed Arslan, Pharm. D., PhD. Coronaviruses are a family of enveloped RNA viruses. Some family members circulate in human populations, but others like severe acute respiratory syndrome coronavirus (SARS-CoV) ar...    Read more.
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