Tmp21/p23 Antibody


Western Blot: TMP21 Antibody [NB110-57587] - Detection of TMP21 in human liver lysate using NB110-57587.

Product Details

Reactivity Hu, Mu, Rt, Bv, Pm, Rb, XpSpecies Glossary
Applications WB, IHC
0.95 mg/ml

Tmp21/p23 Antibody Summary

A synthetic peptide made to an internal sequence of the human TMP21 protein (within residues 50-150). [Swiss-Prot# P49755]
Type I membrane. Golgi cisternae.
Immunogen affinity purified
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Packaging, Storage & Formulations

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
PBS, 30% glycerol
0.1% Sodium Azide
0.95 mg/ml
Immunogen affinity purified


Application Notes
This TMP21 antibody is useful for Immunohistochemistry and Western blot analysis, where a band is seen at ~21 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
21 kDa
Control Peptide
Tmp21/p23 Peptide (NB110-57587PEP)

Reactivity Notes

Human, primate, mouse, rat, cow, Xenopus, and rabbit.

Alternate Names for Tmp21/p23 Antibody

  • 21 kDa transmembrane-trafficking protein
  • p23
  • P24(DELTA)
  • p24delta
  • S31I125
  • S31III125
  • TMED10
  • TMP21Tmp-21-I
  • transmembrane emp24 domain-containing protein 10
  • transmembrane emp24-like trafficking protein 10 (yeast)
  • Transmembrane protein Tmp21,21 kDa transmembrane trafficking protein


TMP21 (transmembrane protein Tmp21) is a type I transmembrane protein with large luminal domain belonging to p24 endoplasmic reticulum/Golgi cargo family and play key roles in protein transport, membrane structure organization and secretory pathway. TMP21 is ubiquitously expressed with highest protein levels observed in pancreas and intestines. In addition to its well established role in vesicle formation and cargo transport in ER/Golgi, TMP21 has been implicated in recruitment of small GTPase ADP-ribosylation factor 1 to Golgi apparatus and ADP-ribosylation factor 1-dependent assembly of actin in the Golgi. TMP21 forms a component of presenilin complex at the plasma membranes and modulates gamma -secretase cleavage. The cytoplasmic tails of p24 family interacts with coatomer (major component of coat protein complex I or COP-I), to facilitate transport between ER and Golgi. TMP21 cycles through the early secretory pathway between intermediate and cis-Golgi compartments, and is essential for proper organization of the Golgi apparatus. TMP21 also plays an essential and non-redundant role in earliest stages of mammalian development.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

View specific protocols for Tmp21/p23 Antibody (NB110-57587): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NB110-57587AF405
Alexa Fluor (R) 488 Labeled NB110-57587AF488
Alexa Fluor (R) 647 Labeled NB110-57587AF647
Alexa Fluor (R) 700 Labeled NB110-57587AF700
Biotin Labeled NB110-57587B
DyLight 405 Labeled NB110-57587V
DyLight 488 Labeled NB110-57587G
DyLight 550 Labeled NB110-57587R
DyLight 650 Labeled NB110-57587C
FITC Labeled NB110-57587F
HRP Labeled NB110-57587H

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Contact Information

Product PDFs


Gene Symbol TMED10

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