Species: Hu, Mu, Rt, Bv, Ch, Pm, Rb
Applications: WB, IHC, KD
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Bv, Pm, Rb, Xp
Applications: WB, IHC, KD
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Species: Hu
Applications: PAGE
Description
TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase, but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites, and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21, indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity and Abeta production, but not epsilon-secretase activity, demonstrating that TMP21 can modulate gamma-secretase activity.
Bioinformatics
| Entrez |
Human
Mouse
Rat
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
10972 |
| Alternate Names |
- 21 kDa transmembrane-trafficking protein
- p23
- P24(DELTA)
- p24delta
- S31I125
- S31III125
- TMP21Tmp-21-I
- transmembrane emp24 domain-containing protein 10
- transmembrane emp24-like trafficking protein 10 (yeast)
- Transmembrane protein Tmp21,21 kDa transmembrane trafficking protein
|
