Tmp21/p23 Products

Tmp21/p23 Antibody
Tmp21/p23 Antibody
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Tmp21/p23 Antibody Blocking P ...
Tmp21/p23 Antibody Blocking Peptide
Species: Hu
Applications: AC
Tmp21/p23 Antibody Blocking P ...
Tmp21/p23 Antibody Blocking Peptide
Species: Hu
Applications: AC
Recombinant Human Tmp21/p23 H ...
Recombinant Human Tmp21/p23 His Pr...
Species: Hu
Applications: PAGE


TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase, but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites, and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21, indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity and Abeta production, but not epsilon-secretase activity, demonstrating that TMP21 can modulate gamma-secretase activity.


Entrez Human
Uniprot Human
Product By Gene ID 10972
Alternate Names
  • p23
  • S31I125
  • transmembrane emp24 domain-containing protein 10
  • 21 kDa transmembrane-trafficking protein
  • Transmembrane protein Tmp21,21 kDa transmembrane trafficking protein
  • p24delta
  • P24(DELTA)
  • TMP21Tmp-21-I
  • S31III125
  • transmembrane emp24-like trafficking protein 10 (yeast)

Diseases related to Tmp21/p23

Discover more about diseases related to Tmp21/p23.

Developmental Delay (disorder)

Pathways for Tmp21/p23

View related products by pathway and learn more about each of the pathways below.

Heart Looping

Research Areas for Tmp21/p23

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Alzheimers Research
Signal Transduction

Bioinformatics Tool for Tmp21/p23

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