TMEM119 Antibody (1023426) [Alexa Fluor® 750]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
1023426
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 750

Order Details

TMEM119 Antibody (1023426) [Alexa Fluor® 750] Summary

Immunogen
Chinese Hamster Ovary cell line, CHO derived human TREM-119
Arg26-Met96
Accession # Q4V9L6.1
Specificity
Detects human TREM-119 in direct ELISAs.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Purity Statement
Protein A or G purified from cell culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25-1 ug/10^6 cells

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TMEM119 Antibody (1023426) [Alexa Fluor® 750]

  • OBIF
  • Osteoblast Induction Factor
  • TMEM119

Background

TMEM119 (Transmembrane Protein 119, also known as Osteoblast Induction Factor or OBIF), is an approximately 38-kDa type 1 transmembrane protein that is predominantly expressed in osteoblasts and is upregulated during osteoblastic differentiation (1, 2). TMEM119 is also expressed in a cell line of microglia, and TMEM119 immunoreactivity is observed in a specific subset of microglia in brains of neurodegenerative diseases, such as Alzheimer's disease (3).  Mature human TMEM119 consists of a 71 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 166 aa cytoplasmic domain. Within the ECD, human TMEM119 shares 78% and 75% aa sequence identity with mouse and rat TMEM119, respectively. TMEM-119 is involved in the osteoblast differentiation and bone development by acting as a ligand and has been reported to contribute to the proliferation, migration, and invasion of osteosarcoma cells, as well as functioning as an oncogene in osteosarcoma (3, 4).




  1. Jiang, Z,H. et al. (2017) Expt & Mol Med. 49:e329.
  2. Mizuhashi, K. et al. (2012) Dev. Growth Differ. 54:474.
  3. Satoh, J. et al. (2016) Neuropathol. 36:39.
  4. Kanamoto, T. et al. (2009) BMC Develop. Biol. 9:70.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 FAB10313U
Alexa Fluor 405 FAB10313V
Alexa Fluor 488 FAB10313G
Alexa Fluor 532 FAB10313X
Alexa Fluor 594 FAB10313T
Alexa Fluor 647 FAB10313R
Alexa Fluor 700 FAB10313N
Alexa Fluor 750 FAB10313S
Allophycocyanin FAB10313A
Biotin FAB10313B
DyLight 350 FAB10313D
DyLight 405 FAB10313E
DyLight 488 FAB10313K
DyLight 550 FAB10313L
DyLight 594 FAB10313M
DyLight 650 FAB10313W
DyLight 680 FAB10313Y
DyLight 755 FAB10313Z
FITC FAB10313F
HRP FAB10313H
Janelia Fluor 549 FAB10313I
Janelia Fluor 646 FAB10313J
PE FAB10313P
PerCP FAB10313C

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Diseases for TMEM119 Antibody (FAB10313S)

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Pathways for TMEM119 Antibody (FAB10313S)

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Blogs on TMEM119.

Antibody treatment can generate microglia-like cells from bone marrow
By Jennifer Sokolowski, MD, PhD.Microglia play important roles in the brain in both homeostatic and pathological conditions, acting to clear debris and dying cells. There is evidence to suggest that microglial dys...  Read full blog post.

TMEM 119 is a specific marker of microglia cells
By Jennifer Sokolowski, MD, PhD.Microglia are a major immune-cell component in the brain. They ingest and degrade dead cells, debris, and foreign material and interact with other immune cells to orchestrate centra...  Read full blog post.

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