TIMP-2 Antibody (3A4)

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Product Details

Summary
Reactivity Hu, Mu, Rt, RbSpecies Glossary
Applications WB, IHC, IHC-P
Clone
3A4
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

TIMP-2 Antibody (3A4) Summary

Immunogen
Human TIMP-2
Specificity
The 3A4 monoclonal antibody was generated from mice immunized with an 11 mer-peptide derived from the sequence of human TIMP-2. The amino acid sequence of this peptide was: DSGNDIYGNPI.
Isotype
IgG2 Alpha
Clonality
Monoclonal
Host
Mouse
Gene
TIMP2
Purity
Tissue culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Publications
Read Publication using NBP1-42375.

Reactivity Notes

Reactivity in other species has not been determined, but the 11-mer peptide used for the immunization shows a 100% match with rat, mouse, and rabbit TIMP-2. The antibody was tested for cross-reactivity with TIMP-1 and did not cross-react. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Hybridoma culture supernatant
Preservative
0.05% Sodium Azide
Purity
Tissue culture supernatant

Notes

For a positive control use Colon carcinoma.

Alternate Names for TIMP-2 Antibody (3A4)

  • CSC-21Ktissue inhibitor of metalloproteinase 2
  • metalloproteinase inhibitor 2
  • TIMP metallopeptidase inhibitor 2
  • TIMP2
  • TIMP-2
  • Tissue inhibitor of metalloproteinases 2

Background

TIMP-2 (Tissue inhibitor of metalloproteinase 2) is a nonglycosylated protein that belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain, predicted molecular weight 24 kD. The mechanisms of TIMPs inhibit angiogenesis appear to be specific for each member of the TIMP family. TIMP-2 binds to the surface of human endothelial cells through interaction with the integrin alpha3 beta1, and abrogates angiogenic factor induced endothelial cell proliferation in vitro and angiogenesis in vivo independent of MMP inhibition. Clone F27P3A4 has been shown to be useful for western blotting, immunohistochemistry and ELISA of human, mouse, rabbit, chicken, zebrafish, and pig TIMP-2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TIMP-2 Antibody (NBP1-42375)(1)

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol TIMP2
Entrez