TIM-2 Antibody (222919)

• Reactivity: Mu
• Applications: WB
• Clone: 222919
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Unconjugated
• Concentration: LYOPH

TIM-2 Antibody (222919) Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse TIM‑2
  His22-Asn229
  Accession # NP_599010
• Specificity: Detects human TIM-2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human TIM-1, recombinant mouse (rm) TIM-1 or rmTIM-3 is observed.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: Timd2
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TIM-2 Antibody (222919)

• G9D3
• T-cell immunoglobulin and mucin domain-containing protein 2
• T-cell immunoglobulin mucin receptor 2
• T-cell membrane protein 2
• TIM2
• TIM-2
• TIMD-2

Background

TIM-2 is a type I transmembrane protein that has an immunoglobulin variable region-like domain followed by a mucin-like domain in its extracellular region. It is selectively expressed on activated T cells and binds to Semaphorin 4A.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TIM-2 Antibody (MAB1885)(2)

Publications using MAB1885

• Brian Chiou, Elizabeth B. Neely, Dillon S. Mcdevitt, Ian A. Simpson, James R. Connor Transferrin and H‐ferritin involvement in brain iron acquisition during postnatal development: impact of sex and genotype Journal of Neurochemistry 2/1/2020 [PMID: 31339576]
• Todorich B, Zhang X, Slagle-Webb B, Seaman WE, Connor JR Tim-2 is the receptor for H-ferritin on oligodendrocytes. J. Neurochem., 2008-11-05;107(6):1495-505. 2008-11-05 [PMID: 19014383] (Western Blot, Rat)

Bioinformatics

• Gene Symbol: Timd2
• Uniprot:
  • NP_599010()