Thrombomodulin/BDCA-3 Antibody (4D8.2C6) [DyLight 350]

• Reactivity: Mu
• Applications: WB, Flow
• Clone: 4D8.2C6
• Clonality: Monoclonal
• Host: Rat
• Conjugate: DyLight 350

Thrombomodulin/BDCA-3 Antibody (4D8.2C6) [DyLight 350] Summary

• Immunogen: Two synthetic peptides made to internal portions of the mouse Thrombomodulin protein (between residues 25-150 and 400-550) [UniProt P07204]
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Rat
• Gene: THBD
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Thrombomodulin/BDCA-3 Antibody (4D8.2C6) [DyLight 350]

• BDCA3
• BDCA-3
• CD141 antigen
• CD141
• Fetomodulin
• THBD
• THRM
• Thrombomodulin
• TM

Background

CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: THBD