TGF-beta Antibody (1D11.16.8) [Janelia Fluor® 549]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, Ca, Ha, PmSpecies Glossary
Applications ICC/IF, IHC, IHC-P, S-ELISA
Clone
1D11.16.8
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 549

TGF-beta Antibody (1D11.16.8) [Janelia Fluor® 549] Summary

Immunogen
Bovine bone-derived TGF-beta 1 and TGF-beta 2
Specificity
This MAb recognizes TGF beta 1, 2 and 3. Three TGF betas have been identified in mammals. TGFbeta1, TGFbeta2 and TGFbeta3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFbeta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFbeta3 protein has approximately 80% identity to the mature region of both TGFbeta1 and TGFbeta2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGFbeta's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TGFB1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Sandwich ELISA
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for TGF-beta Antibody (1D11.16.8) [Janelia Fluor® 549]

  • CED
  • DPD1
  • LAP
  • TGFB
  • TGFB1
  • TGFbeta
  • TGF-beta
  • transforming growth factor beta 1

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

ICC/IF Video Protocol

FAQs for TGF-beta Antibody (NBP2-45137JF549) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-45137AF350
Alexa Fluor 405 NBP2-45137AF405
Alexa Fluor 488 NBP2-45137AF488
Alexa Fluor 532 NBP2-45137AF532
Alexa Fluor 594 NBP2-45137AF594
Alexa Fluor 647 NBP2-45137AF647
Alexa Fluor 700 NBP2-45137AF700
Alexa Fluor 750 NBP2-45137AF750
Biotin NBP2-45137B
DyLight 350 NBP2-45137UV
DyLight 405 NBP2-45137V
DyLight 488 NBP2-45137G
DyLight 550 NBP2-45137R
DyLight 594 NBP2-45137DL594
DyLight 650 NBP2-45137C
DyLight 680 NBP2-45137FR
DyLight 755 NBP2-45137IR
FITC NBP2-45137F
HRP NBP2-45137H
Janelia Fluor 549 NBP2-45137JF549
Janelia Fluor 646 NBP2-45137JF646

Additional TGF-beta Products

Array NBP2-45137JF549

Bioinformatics Tool for TGF-beta Antibody (NBP2-45137JF549)

Discover related pathways, diseases and genes to TGF-beta Antibody (NBP2-45137JF549). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for TGF-beta Antibody (NBP2-45137JF549)

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Pathways for TGF-beta Antibody (NBP2-45137JF549)

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PTMs for TGF-beta Antibody (NBP2-45137JF549)

Learn more about PTMs related to TGF-beta Antibody (NBP2-45137JF549).

Blogs on TGF-beta.

Neurovascular signaling for repair enhances brain metastasis
By Jamshed Arslan, Pharm. D., PhD. Stroke    is a leading cause of mortality and morbidity worldwide. Cellular players – neurons, astrocytes, endothelial and stromal cells – involved in post-stroke repair t...  Read full blog post.

Bad news for stomach cancer: BAMBI protein inhibits gastric carcinoma via TGF-beta/epithelial-mesenchymal transition signaling
By Jamshed Arslan Pharm.D. Gastric carcinoma is the second leading cause of cancer-related deaths worldwide. One of the key features of gastric carcinoma is acidosis, which promotes growth and metastasis of gastric...  Read full blog post.

You complete me: Natural killer cells need TGF-beta inhibition to effectively combat cancers
By Jamshed Arslan Pharm.D. Natural killer (NK) cells are lymphocytes of the innate immune system that were first discovered for their “natural” ability to kill cancer cells. To use NK cells as anti-cancer therapy, t...  Read full blog post.

TGF-beta for treating degenerative intervertebral disc disease
By Jamshed Arslan Pharm.D. Our upright posture and balance depend on a jelly-like material, called nucleus pulposus (NP), in the middle of intervertebral discs. NP cells protect us from disc degeneration by maintain...  Read full blog post.

Stemness for Surviving Hypoxia: TGF-beta/Smad Signaling in Multiple Myeloma
By Jamshed Arslan Pharm.D. Multiple myeloma (MM) is a cancer of antibody-producing plasma cells. The bone marrow (BM) of MM patients is hypoxic, and MM cells overexpress many cancerous genes that are regulated by hy...  Read full blog post.

TGF-beta RIII - A multi-functional regulator of the TGF-beta signaling pathway
Transforming growth factor-beta receptor III (TGF-beta RIII) is one of three receptors for the secreted growth factor TGF-beta. Unlike type I and type II TGF-beta receptors, TGF-beta RIII does not participate directly in the propagation of intracel...  Read full blog post.

CCR2 or CD192
CCR2 is a receptor for several monocyte chemoattractant proteins (MCP1, MCP3, MCP4) that specifically govern monocyte chemotaxis. CCR2 transduces its downstream signals through increasing intracellular calcium ion levels. For example, MCP1 regulate...  Read full blog post.

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Bioinformatics

Gene Symbol TGFB1