TFPI Antibody

Western Blot: TFPI Antibody [H00007035-D01P] - Analysis of TFPI expression in mouse liver.

Western Blot: TFPI Antibody [H00007035-D01P] - Analysis of TFPI expression in transfected 293T cell line by TFPI polyclonal antibody.Lane 1: TFPI transfected lysate(35.00 KDa).Lane 2: Non-transfected lysate.

Product Discontinued

TFPI Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: TFPI (NP_006278.1, 1 a.a. - 304 a.a.) full-length human protein. MIYTMKKVHALWASVCLLLNLAPAPLNADSEEDEEHTIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTRDNANRIIKTTLQQEKPDFCFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDGPNGFQVDNYGTQLNAVNNSLTPQSTKVPSLFEFHGPSWCLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKKGFIQRISKGGLIKTKRKRKKQRVKIAYEEIFVKNM
• Specificity: Reacts with tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TFPI
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: This antibody is reactive against tissue and transfected lysate in WB and as a detection antibody in ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for TFPI Antibody

• convertin
• EPI
• EPITFPI1LACITFI
• Extrinsic pathway inhibitor
• LACI
• Lipoprotein-associated coagulation inhibitor
• TFPI
• tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
• tissue factor pathway inhibitor

Background

This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TFPI Antibody (H00007035-D01P)(1)

Publication using H00007035-D01P

• Obi AT, Andraska E, Kanthi Y et al. Endotoxaemia-augmented murine venous thrombosis is dependent on TLR-4 and ICAM-1, and potentiated by neutropenia Thromb. Haemost. 2017-01-26 [PMID: 27975098] (WB, Mouse)

Bioinformatics

• Gene Symbol: TFPI
• Entrez:
  • 7035(Human)
• Uniprot:
  • NP_006278.1(Human)