TFF1/pS2 Antibody (SPM573) [PE]

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Product Details

Summary
Reactivity Hu, Pm-CmSpecies Glossary
Applications Flow
Clone
SPM573
Clonality
Monoclonal
Host
Mouse
Conjugate
PE

Order Details

TFF1/pS2 Antibody (SPM573) [PE] Summary

Immunogen
Synthetic peptide of 28 amino acid residues corresponding to CFDDTVRGVPWCFYPNTIDVPPEEECEF (aa57-84) from the C-terminus of human TFF1/pS2.
Localization
Cytoplasmic
Specificity
It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TFF1
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Flow Cytometry

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for TFF1/pS2 Antibody (SPM573) [PE]

  • BCEI
  • BCEIbreast cancer, estrogen-inducible sequence expressed in
  • Breast cancer estrogen-inducible protein
  • breast cancer estrogen-inducible sequence
  • D21S21
  • gastrointestinal trefoil protein pS2
  • hP1.A
  • HPS2
  • PNR-2
  • Polypeptide P1.A
  • Protein pS2
  • PS2
  • TFF1
  • trefoil factor 1
  • trefoil factor, BCE1, human pS2 induced by estrogen from human breast cancercell line M10HP1.A

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-34806AF350
Alexa Fluor 405 NBP2-34806AF405
Alexa Fluor 488 NBP2-34806AF488
Alexa Fluor 532 NBP2-34806AF532
Alexa Fluor 594 NBP2-34806AF594
Alexa Fluor 647 NBP2-34806AF647
Alexa Fluor 700 NBP2-34806AF700
Alexa Fluor 750 NBP2-34806AF750
Allophycocyanin NBP2-34806APC
Biotin NBP2-34806B
DyLight 350 NBP2-34806UV
DyLight 405 NBP2-34806V
DyLight 488 NBP2-34806G
DyLight 550 NBP2-34806R
DyLight 594 NBP2-34806DL594
DyLight 650 NBP2-34806C
DyLight 680 NBP2-34806FR
DyLight 755 NBP2-34806IR
FITC NBP2-34806F
HRP NBP2-34806H
Janelia Fluor 549 NBP2-34806JF549
Janelia Fluor 646 NBP2-34806JF646
PE NBP2-34806PE
PerCP NBP2-34806PCP

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Bioinformatics Tool for TFF1/pS2 Antibody (NBP2-34806PE)

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Bioinformatics

Gene Symbol TFF1