TFF1/pS2 Antibody (GE2 (same as R47/94)) [DyLight 405]

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Product Details

Summary
Reactivity Hu, PmSpecies Glossary
Applications WB, ELISA, Flow, ICC/IF, IHC-Fr, IHC-P
Clone
GE2 (same as R47/94)
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 405

Order Details

TFF1/pS2 Antibody (GE2 (same as R47/94)) [DyLight 405] Summary

Immunogen
Synthetic peptide of 28 amino acid residues corresponding to CFDDTVRGVPWCFYPNTIDVPPEEECEF (aa57-84) from the C-terminus of human pS2.
Localization
Cytoplasmic
Specificity
It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TFF1
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin

Reactivity Notes

Cynomolgus Monkey

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for TFF1/pS2 Antibody (GE2 (same as R47/94)) [DyLight 405]

  • BCEI
  • BCEIbreast cancer, estrogen-inducible sequence expressed in
  • Breast cancer estrogen-inducible protein
  • breast cancer estrogen-inducible sequence
  • D21S21
  • gastrointestinal trefoil protein pS2
  • hP1.A
  • HPS2
  • PNR-2
  • Polypeptide P1.A
  • Protein pS2
  • PS2
  • TFF1
  • trefoil factor 1
  • trefoil factor, BCE1, human pS2 induced by estrogen from human breast cancercell line M10HP1.A

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for TFF1/pS2 Antibody (NBP2-34623V) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-34623AF350
Alexa Fluor 405 NBP2-34623AF405
Alexa Fluor 488 NBP2-34623AF488
Alexa Fluor 532 NBP2-34623AF532
Alexa Fluor 594 NBP2-34623AF594
Alexa Fluor 647 NBP2-34623AF647
Alexa Fluor 700 NBP2-34623AF700
Alexa Fluor 750 NBP2-34623AF750
Allophycocyanin NBP2-34623APC
Allophycocyanin/Cy7 NBP2-34623APCCY7
Biotin NBP2-34623B
DyLight 350 NBP2-34623UV
DyLight 405 NBP2-34623V
DyLight 488 NBP2-34623G
DyLight 550 NBP2-34623R
DyLight 594 NBP2-34623DL594
DyLight 650 NBP2-34623C
DyLight 680 NBP2-34623FR
DyLight 755 NBP2-34623IR
HRP NBP2-34623H
Janelia Fluor 549 NBP2-34623JF549
Janelia Fluor 646 NBP2-34623JF646
PE NBP2-34623PE
PE/Atto594 NBP2-34623PEATT594
PE/Cy5.5 NBP2-34623PECY55
PE/Cy7 NBP2-34623PECY7

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Bioinformatics

Gene Symbol TFF1