Tenascin X Antibody (766842) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 766842
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

Tenascin X Antibody (766842) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human Tenascin XB2 in ELISAs and Western blots. Also detects Tenascin X in Western blots. In direct ELISAs, no cross-reactivity with recombinant human Tenascin R is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Tenascin X Antibody (766842) [Alexa Fluor™ Plus 647]

• Hexabrachion-like protein
• HXBL
• Tenascin X
• tenascin XB
• tenascin XB2
• tenascin-X
• TNX
• TNXB
• TNXB1growth-inhibiting protein 45
• TNXB2tenascin XB1
• TNXBS
• TNXBSTNXTENX
• XB
• XBS
• XB-S
• XBTN-X

Background

Tenascin XB2 (TN-XB2; also TN-XB-Short/S and tenascin-X isoform 2) is a 73-75 kDa member of the tenascin family of extracellular matrix molecules. It is expressed by adrenal gland, and represents the use of an intronic promoter that is tied to an internal start site within the TN-XB gene. A duplication of the TN-XB2 region has created a gene called TN-XA that codes for the same ORF but is not translated. Although TN-XB2 has been reported to bind to tropoelastin, plus collagens I, III and V, other studies using soluble fragments of TN-XB report only tropoelastin interaction. Human TN-XB2 is 673 amino acids (aa) in length. It contains four fibronectin type III repeats (aa 82-442), and one C-terminal fibrinogen-like globular region (aa 449-664). Antibodies to TN-XB2 recognize full-length 465 kDA Tenascin X (TN-XB), 75 kDa and 140-150 kDa C-terminal fragments. Although human TN-XB2 shares 84% aa identity with full-length mouse TN-XB in its C-terminus, there does not appear to be an equivalent alternative start site in the mouse gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.