Tenascin C Antibody (4C8MS) [DyLight 488]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clone
4C8MS
Clonality
Monoclonal
Host
Mouse

Tenascin C Antibody (4C8MS) [DyLight 488] Summary

Immunogen
Recombinant human Tenascin C [Swiss-Prot# P24821].
Localization
Secreted > extracellular space > extracellular matrix
Specificity
NB110-68136 specifically reacts with Domain B on FNIII repeats of Tenascin C.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TNC
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Conjugate
DyLight 488
Format
DyLight 488 (A=493, E=518)
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Applications/Dilutions

Dilutions
  • Western Blot 5 ug/ml
  • Immunocytochemistry/Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:50
  • Immunohistochemistry-Paraffin 1:50
Application Notes
This Tenascin C (4C8MS) antibody is useful for Immunohistochemistry on paraffin-embedded sections, Immunocytochemistry/Immunofluorescence (PMID: 21871891) and Western blot. Immunohistochemistry-Frozen and ELISA were reported in scientific literature.

Reactivity Notes

Human, mouse and rat.

Alternate Names for Tenascin C Antibody (4C8MS) [DyLight 488]

  • 150-225
  • Cytotactin
  • Glioma-associated-extracellular matrix antigen
  • GMEM
  • GP 150-225
  • hexabrachion (tenascin C, cytotactin)
  • hexabrachion (tenascin)
  • Hexabrachion
  • HXB
  • HXBcytotactin
  • JI
  • MGC167029
  • Myotendinous antigen
  • neuronectin
  • Tenascin C
  • Tenascin J1
  • tenascin
  • tenascin-C isoform 14/AD1/16
  • Tenascin-C
  • TNC
  • TN-C
  • TNGP

Background

In most tissues of adults, tenascin C is rarely present at significant levels. However, in developing tissues, or tissues experiencing a fast rate of growth, tenascin C is upregulated. This effect is particularly evident when this extracellular matrix glycoprotein is found in abundance in tissues responding to injury or infection. When muscular pH is increased, tenascin C production also increases. Prostate smooth muscle cells produce extra tenascin C when responding to LPS infection. In fibrosis and stenosis, tenascin C expression levels are markedly increased, and the protein seems to function as a mobilizer of immune cells responding to tissue damage and repair. In COPD, likewise, tenascin C expression is increased and is associated with cells attempting to repair damage within the lung. In short, tenascin C can be expected to be found in adult tissues only when associated with tissue damage and repair efforts.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Tenascin C Antibody (NB110-68136G). (Showing 1 - 1 of 1 FAQ).

  1. One of our clients is looking for antibodies against tenascin C and fibronectin that could be used for FFPE rat tissues. These antibodies should exclusively recognize tenascin C and fibronectin and do not cross react with each other. Can you inform me if you have these antibodies?
    • Here is a link to Tenascin C antibodies we have validated in rat tissues for IHC-P Here are antibodies we have validated in fibronectin in rat tissues for IHC-P

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Allophycocyanin Labeled NB110-68136APC
Biotin Labeled NB110-68136B
DyLight 350 Labeled NB110-68136UV
DyLight 405 Labeled NB110-68136V
DyLight 405LS Labeled NB110-68136V3
DyLight 550 Labeled NB110-68136R
DyLight 650 Labeled NB110-68136C
DyLight 680 Labeled NB110-68136FR
DyLight 755 Labeled NB110-68136IR
FITC Labeled NB110-68136F
HRP Labeled NB110-68136H
PE Labeled NB110-68136PE
PerCP Labeled NB110-68136PCP

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Blogs on Tenascin C

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Contact Information

Product PDFs

Bioinformatics

Gene Symbol TNC
Entrez
Uniprot

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