TEM7/PLXDC1 Antibody Blocking Peptide

Product Discontinued

TEM7/PLXDC1 Antibody Blocking Peptide Summary

• Description: A blocking peptide containing 16 amino acids near the carboxy terminus of human TEM7.

  Source: Synthetic

  (Accession #: AAG00869)

• Source: Synthetic
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: PLXDC1
• Purity: N/A

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This peptide is useful as a blocking peptide for NBP1-76832.
  
  For further blocking peptide related protocol, click here.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin.
• Preservative: 0.02% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: N/A

Alternate Names for TEM7/PLXDC1 Antibody Blocking Peptide

• FLJ45632
• plexin domain containing 1,2410003I07Rik
• plexin domain-containing protein 1
• PLXDC1
• TEM3
• TEM3FLJ36270
• TEM7
• TEM7DKFZp686F0937
• Tumor endothelial marker 3
• Tumor endothelial marker 7

Background

Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: PLXDC1