TCL1A Antibody

Images

 
Western Blot: TCL1 Antibody [NB100-77332] - (0.1ug/ml) staining of Jurkat Cell lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

TCL1A Antibody Summary

Immunogen
Peptide with sequence C-QLYPDGRYRSSD corresponding to internal region according to NP_068801.1.
Epitope
QLYPDGRYRSSD
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
TCL1A
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 - 0.3 ug/ml
  • Peptide ELISA Detection limit 1:32000
Application Notes
WB: Approx. 16 kDa band observed in Daudi and Jurkat lysates (calculated MW of 13.5 kDa band according to NP_068801.1).
Publications
Read Publication using NB100-77332.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Tris (pH 7.3), 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for TCL1A Antibody

  • Oncogene TCL1
  • Oncogene TCL-1
  • Protein p14 TCL1
  • T-cell leukemia/lymphoma 1A
  • T-cell lymphoma-1
  • T-cell lymphoma-1A
  • TCL1A
  • TCL1-PEN
  • TCL1T-cell leukemia/lymphoma protein 1A

Background

The T-cell leukaemia/lymphoma 1 (TCL1)-family oncoproteins augment AKT signal transduction and enhance cell proliferation and survival. Chromosome rearrangements, faulty developmental silencing and Epstein-Barr virus infection appear to dysregulate the expression of TCL1-family genes, provoking several important types of lymphocyte cancer. A key role for TCL1 proteins in cell transformation has been established in studies of transgenic mouse models, which develop a unique spectrum of T- and B-cell malignancies. How TCL1 proteins are regulated and dysregulated, how they promote transformation and the potential for therapies modelled on TCL1 interactions have important implications for understanding and treating lymphocyte cancers.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TCL1A Antibody (NB100-77332)(1)

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Bioinformatics

Gene Symbol TCL1A
Entrez
Uniprot